验证数据展示
产品信息
81853-1-PBS targets CD11c/Integrin alpha X in IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
Tested Applications | IHC, IF/ICC, Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | CD11c/Integrin alpha X fusion protein Ag11380 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | integrin, alpha X (complement component 3 receptor 4 subunit) |
Synonyms | CD11c, ITGAX, Integrin alpha-X, Integrin alpha X, CD11 antigen-like family member C |
Calculated Molecular Weight | 1169 aa, 129 kDa |
GenBank Accession Number | BC038237 |
Gene Symbol | CD11c |
Gene ID (NCBI) | 3687 |
ENSEMBL Gene ID | ENSG00000140678 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P20702 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11c, also known as integrin αX, is a type I transmembrane glycoprotein present on a variety of cells, including monocytes/macrophages, granulocytes, a subset of B cells, NK cells and dendritic cells (PMID: 2897326; 1680915; 1694698; 17389580). As a result of its high level of expression on most dendritic cells, CD11c is typically considered to be a marker of conventional dendritic cells (PMID: 27119555). CD11c forms an α/β heterodimer with CD18 (integrin β2). CD11c/CD18 acts a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis (PMID: 1671533).