• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Anti-Human CD141/Thrombomodulin Rabbit Recombinant Antibody, PBS Only

CD141/Thrombomodulin Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

240365E11

Cat no : 98037-1-PBS

Print datasheet

Synonyms

THBD, Thrombomodulin, THRM, Fetomodulin, CD141

验证数据展示

  • FC experiment of human peripheral blood leukocyte using 98037-1-RR (same clone as 98037-1-PBS)

    FC experiment of human peripheral blood leukocyte using 98037-1-RR (same clone as 98037-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD141/Thrombomodulin Rabbit Recombinant Antibody (98037-1-RR, Clone: 240365E11) or Isotype Control and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining.Cells were not fixed. This data was developed using the same antibody clone with 98037-1-PBS in a different storage buffer formulation.

  • FC experiment of human peripheral blood leukocyte using 98037-1-RR (same clone as 98037-1-PBS)

    FC experiment of human peripheral blood leukocyte using 98037-1-RR (same clone as 98037-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human Thrombomodulin Rabbit Recombinant Antibody (98037-1-RR, Clone: 240365E11) (red) or Isotype Control (blue), and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98037-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98037-1-RR

    Affinity and Kinetic Characterization of 98037-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98037-1-RR against Human CD141/Thrombomodulin were performed. The affinity constant is 1.83 nM.

产品信息

The immunogen of 98037-1-PBS is CD141/Thrombomodulin Fusion Protein expressed in E. coli.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Fusion Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name thrombomodulin
Synonyms THBD, Thrombomodulin, THRM, Fetomodulin, CD141
Calculated Molecular Weight60 kDa
GenBank Accession NumberNM_000361.3
Gene Symbol THBD
Gene ID (NCBI) 7056
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP07204
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Thrombomodulin, also known as CD141, is an endothelial cell surface glycoprotein that forms a 1:1 complex with the coagulation factor thrombin and plays an important role as a natural anticoagulant. Thrombomodulin serves to convert thrombin from a procoagulant protein into the activator for protein C. Once converted to activated protein C (APC), this protein serves as a major anticoagulant in blood (PMID: 2827310). Thrombomodulin is also located in other cells (keratinocytes, osteoblasts, macrophages,...) where it might be involved in cell differentiation or in inflammation (PMID: 9814688). In humans, thrombomodulin is encoded by the THBD gene. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. Thrombomodulin is glycosylated and has an apparent molecular weight of 75 to 110 kDa (PMID: 1650405; 2827310).