验证数据展示
经过测试的应用
Positive FC detected in | human peripheral blood leukocytes |
推荐稀释比
应用 | 推荐稀释比 |
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This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
98037-2-RR targets CD141/Thrombomodulin in FC applications and shows reactivity with human samples.
经测试应用 | FC Application Description |
经测试反应性 | human |
免疫原 | Fusion Protein 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | thrombomodulin |
别名 | THBD, Thrombomodulin, THRM, Fetomodulin, CD141 |
计算分子量 | 60 kDa |
GenBank蛋白编号 | NM_000361.3 |
基因名称 | THBD |
Gene ID (NCBI) | 7056 |
RRID | AB_3672183 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purfication |
UNIPROT ID | P07204 |
储存缓冲液 | PBS with 0.09% sodium azide , pH 7.3 |
储存条件 | Store at 2 - 8°C. Stable for one year after shipment. |
背景介绍
Thrombomodulin, also known as CD141, is an endothelial cell surface glycoprotein that forms a 1:1 complex with the coagulation factor thrombin and plays an important role as a natural anticoagulant. Thrombomodulin serves to convert thrombin from a procoagulant protein into the activator for protein C. Once converted to activated protein C (APC), this protein serves as a major anticoagulant in blood (PMID: 2827310). Thrombomodulin is also located in other cells (keratinocytes, osteoblasts, macrophages,...) where it might be involved in cell differentiation or in inflammation (PMID: 9814688). In humans, thrombomodulin is encoded by the THBD gene. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. Thrombomodulin is glycosylated and has an apparent molecular weight of 75 to 110 kDa (PMID: 1650405; 2827310).
实验方案
Product Specific Protocols | |
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FC protocol for CD141/Thrombomodulin antibody 98037-2-RR | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |