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Anti-Human CD155/PVR Rabbit Recombinant Antibody, PBS Only

CD155/PVR Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241405G8

Cat no : 98186-1-PBS

Print datasheet

Synonyms

PVR, NECL-5, NECL5, Necl 5, HVED

验证数据展示

  • FC experiment of human PBMCs using 98186-1-RR (same clone as 98186-1-PBS)

    FC experiment of human PBMCs using 98186-1-RR (same clone as 98186-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD155/PVR Rabbit Recombinant Antibody (98186-1-RR, Clone: 241405G8) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98186-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98186-1-RR (same clone as 98186-1-PBS)

    FC experiment of human PBMCs using 98186-1-RR (same clone as 98186-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD155/PVR Rabbit Recombinant Antibody (98186-1-RR, Clone: 241405G8) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98186-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy PVR Ready-To-Use IHC Kit. PVR primary antibody included.

产品信息

The immunogen of 98186-1-PBS is CD155/PVR Fusion Protein expressed in E. coli.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Fusion Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name poliovirus receptor
Synonyms PVR, NECL-5, NECL5, Necl 5, HVED
Calculated Molecular Weight 45 kDa
GenBank Accession NumberBC015542
Gene Symbol CD155/PVR
Gene ID (NCBI) 5817
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP15151
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD155, also known as PVR, is a type I transmembrane glycoprotein in the immunoglobulin superfamily. It contains three extracellular immunoglobulin-like domains, D1-D3, of which D1 is recognized by the virus. Mature human CD155 consists of a 323 amino acid extracellular domain with one N-terminal V-type and two C2-type Ig-like domains, a 24 amino acid transmembrane segment, and a 50 amino acid cytoplasmic tail. CD155 is thought to play a role in adhesion by interaction with the ECM component vitronectin as well as a role in NK killing of tumor cells. CD155 binds to two receptors of NK cells, CD96 and CD226, and accumulates at cell-cell contact sites, leading to the formation of mature immune synapses between NK cells and target cells. CD155 serves as the entry receptor for poliovirus and thereby mediates human susceptibility to poliovirus infection.