验证数据展示
产品信息
65612-1-PBS targets CD16 in FC applications and shows reactivity with human samples.
Tested Applications | FC Application Description |
Tested Reactivity | human |
Immunogen | N/A 种属同源性预测 |
Host / Isotype | Mouse / IgG2a |
Class | Recombinant |
Type | Antibody |
Full Name | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) |
Synonyms | Fc gamma RIII alpha, Fc gamma RIII, CD16-II, CD16a antigen, CD16A |
Calculated Molecular Weight | 254 aa, 29 kDa |
GenBank Accession Number | BC017865 |
Gene Symbol | CD16a |
Gene ID (NCBI) | 2214 |
ENSEMBL Gene ID | ENSG00000203747 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CD16 is a 50-70-kDa low affinity Fc receptor found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16 mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), encoded by two nearly identical genes, FCGR3A and the FCGR3B. Clone 3G8 recognizes both the CD16a and CD16b (PMID: 7592758).