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Anti-Human CD200 Rabbit Recombinant Antibody, PBS Only

CD200 Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241347E1

Cat no : 98091-1-PBS

Print datasheet

Synonyms

OX 2, MRC, MOX2, MOX1, CD200 molecule

验证数据展示

  • FC experiment of human PBMCs using 98091-1-RR (same clone as 98091-1-PBS)

    FC experiment of human PBMCs using 98091-1-RR (same clone as 98091-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD200 Rabbit Recombinant Antibody (98091-1-RR, Clone:241347E1) or 0.25 ug Isotype Control and PE-conjugated Goat Anti-Rabbit IgG. Cell were then stained with CoraLite® Plus 647 Anti-Human CD19 (4G7). Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98091-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98091-1-RR

    Affinity and Kinetic Characterization of 98091-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98091-1-RR against Human CD200 were performed. The affinity constant is 1.15 nM.

产品信息

98091-1-PBS targets CD200 in FC applications and shows reactivity with human samples.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Recombinant Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name CD200 molecule
Synonyms OX 2, MRC, MOX2, MOX1, CD200 molecule
Calculated Molecular Weight 269 aa, 30 kDa
GenBank Accession NumberBC022522
Gene Symbol CD200
Gene ID (NCBI) 4345
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP41217
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD200, also known as OX2, is a type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily (PMID: 3032785). It contains two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. CD200 is expressed on a variety of cell types, including thymocytes, B lymphocytes, a subset of T lymphocytes, follicular dendritic cells, neurons, and endothelial cells (PMID: 3032785; 10981966). CD200 binds to its receptor, CD200R, which is primarily expressed by myeloid and T cell lineage (PMID: 15187158). The CD200-CD200R interaction plays a role in immunosuppression and suppression of anti-tumor immune responses (PMID: 22020332).