验证数据展示
产品信息
65578-1-PBS targets CD45RA in FC applications and shows reactivity with rat samples.
Tested Applications | FC Application Description |
Tested Reactivity | rat |
Immunogen | Leukocyte common antigen purified from rat splenocytes 种属同源性预测 |
Host / Isotype | Mouse / IgG2a |
Class | Recombinant |
Type | Antibody |
Full Name | protein tyrosine phosphatase, receptor type, C |
Synonyms | Lca, Ptprc, CD45, RT7, OX-33 |
Calculated Molecular Weight | 143 kDa |
GenBank Accession Number | XM_006249910 |
Gene Symbol | CD45 |
Gene ID (NCBI) | 24699 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CD45, also known as protein tyrosine phosphatase, receptor type C, is a type I transmembrane protein expressed on the surface of all haematopoietic cells with the exception of erythrocytes and platelets (PMID: 3489673; 28615666). CD45 is a pan-haematopoietic cell marker and has been shown to be essential for T- and B-cell activation and signaling (PMID: 9429890; 16378097). CD45 exists as multiple isoforms due to alternative splicing of three exons (4, 5, and 6, designated A, B, and C) in the extracellular domain (PMID: 12414720). CD45RA is expressed on naïve T cells, B cells, and monocytes (PMID: 1830500; 14687231).