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Anti-Human CD72 Rabbit Recombinant Antibody, PBS Only

CD72 Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241300C1

Cat no : 98090-1-PBS

Print datasheet

Synonyms

LYB2, Lyb 2, CD72b, CD72 molecule, B-cell differentiation antigen CD72

验证数据展示

  • FC experiment of human PBMCs using 98090-1-RR (same clone as 98090-1-PBS)

    FC experiment of human PBMCs using 98090-1-RR (same clone as 98090-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD72 Rabbit Recombinant Antibody (98090-1-RR, Clone:241300C1) , or Isotype Control and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD19. Cells were not fixed. This data was developed using the same antibody clone with 98090-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98090-1-RR (same clone as 98090-1-PBS)

    FC experiment of human PBMCs using 98090-1-RR (same clone as 98090-1-PBS)

    1x10^6 human PBMCs were stained with 0.25 ug Anti-Human CD72 Rabbit Recombinant Antibody (98090-1-RR, Clone:241300C1)(red) , or Isotype Control(blue) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).Cells were not fixed. This data was developed using the same antibody clone with 98090-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98090-1-RR

    Affinity and Kinetic Characterization of 98090-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98090-1-RR against Human CD72 were performed. The affinity constant is 10.7 nM.

产品信息

98090-1-PBS targets CD72 in FC applications and shows reactivity with human samples.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Recombinant Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name CD72 molecule
Synonyms LYB2, Lyb 2, CD72b, CD72 molecule, B-cell differentiation antigen CD72
Calculated Molecular Weight 359 aa, 40 kDa
GenBank Accession NumberBC030227
Gene Symbol CD72
Gene ID (NCBI) 971
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP21854
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD72 is a type II transmembrane glycoprotein of 39-45 kDa and is expressed as a disulphide-linked homodimer (PMID: 1711157). CD72 is a pan B-cell marker covering the full range of differentiation from the very early stages of B cells to mature surface Ig+ B cells (PMID: 1384316). It is expressed in all stages of B cell development except plasma cells. CD72 is also expressed by dendritic cells, tissue macrophages in the red pulp of the spleen and von Kupffer cells in the liver (PMID: 8561576; 1384316). CD72 is the ligand for CD5 (PMID: 1711157). CD72 is a negative regulator of BCR signaling (PMID: 9590210). Interaction of CD100 with CD72 strictly tunes the strength of BCR signals and is essential for maintaining immunological homeostasis as well as generating a proper immune response (PMID: 16113236).