FITC Plus Anti-Mouse CD80 (B7-1) (16-10A1)
CD80 (B7-1) Monoclonal Antibody for FC
Host / Isotype
Armenian Hamster / IgG
Reactivity
Mouse and More (1)
Applications
FC and More (1)
Conjugate
FITC Plus Fluorescent Dye
CloneNo.
16-10A1
验证数据展示
经过测试的应用
| Positive FC detected in | mouse peritoneal macrophages |
推荐稀释比
| Application | Dilution |
|---|---|
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
发表文章中的应用
| IF | See 1 publications below |
| FC | See 7 publications below |
产品信息
FITC-65076 targets CD80 (B7-1) in IF, FC applications and shows reactivity with Mouse samples.
| Tested Applications | FC |
| Cited Applications | FC, IF |
| Tested Reactivity | Mouse |
| Cited Reactivity | mouse |
| Immunogen | CHO cell line transfected with mouse B7 (CD80) 种属同源性预测 |
| Host / Isotype | Armenian Hamster / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | CD80 antigen |
| Synonyms | B7 1, B7.1, Cd28l, Cd80, CD80 (B7-1), CD80 antigen, Ly 53, Ly53, MIC17, TS/A 1 |
| GenBank Accession Number | BC131959 |
| Gene Symbol | Cd80 |
| Gene ID (NCBI) | 12519 |
| RRID | AB_2883762 |
| Conjugate | FITC Plus Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 495 nm / 524 nm |
| Form | Liquid |
| Purification Method | Affinity purification |
| UNIPROT ID | Q00609 |
| Storage Buffer | PBS with 0.09% sodium azide. |
| Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
CD80 (also known as B7-1) is a type I membrane protein that is a member of the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, monocytes, and macrophages. CD80 is the receptor for the proteins CD28 and CTLA-4 found on the surface of T-cells. It is involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. CD80 also acts as a cellular attachment receptor for adenovirus subgroup B. (PMID: 7545666; 12015893; 16920215)
实验方案
| Product Specific Protocols | |
|---|---|
| FC protocol for FITC Plus CD80 (B7-1) antibody FITC-65076 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
ACS Appl Mater Interfaces Combined Chemo-Immuno-Photothermal Therapy for Effective Cancer Treatment via an All-in-One and One-for-All Nanoplatform | ||
ACS Appl Mater Interfaces Intelligent Nanoplatform Integrating Macrophage and Cancer Cell Membrane for Synergistic Chemodynamic/Immunotherapy/Photothermal Therapy of Breast Cancer | ||
Cell Rep Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells | ||
Neurobiol Dis Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice. | ||
Nat Commun CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis | ||
Pharmaceutics Development and Evaluation of a Novel Diammonium Glycyrrhizinate Phytosome for Nasal Vaccination |