Anti-Human CD80 (B7-1) (2D10.4)
CD80 (B7-1) Monoclonal Antibody for FC
Host / Isotype
Mouse / IgG1, kappa
Reactivity
Human and More (1)
Applications
FC
Conjugate
Unconjugated
CloneNo.
2D10.4
验证数据展示
经过测试的应用
Positive FC detected in | Daudi cells |
Planning an IF experiment? We recommend our CoraLite® Plus 647 conjugated versions of this antibody.
推荐稀释比
Application | Dilution |
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This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
发表文章中的应用
FC | See 1 publications below |
产品信息
65083-1-Ig targets CD80 (B7-1) in FC applications and shows reactivity with Human samples.
Tested Applications | FC Application Description |
Cited Applications | FC |
Tested Reactivity | Human |
Cited Reactivity | human |
Immunogen | N/A 种属同源性预测 |
Host / Isotype | Mouse / IgG1, kappa |
Class | Monoclonal |
Type | Antibody |
Full Name | CD80 molecule |
Synonyms | Activation B7 1 antigen, B7, B7 1, BB1, CD28LG, CD28LG1, CD80, CD80 (B7-1), CD80 molecule, CTLA 4 counter receptor B7.1, LAB7 |
Calculated Molecular Weight | 33 kDa |
GenBank Accession Number | BC042665 |
Gene Symbol | CD80 |
Gene ID (NCBI) | 941 |
RRID | AB_2918386 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Affinity purification |
Storage Buffer | PBS with 0.1% sodium azide, pH 7.3. |
Storage Conditions | Store at 2-8°C. Stable for one year after shipment. |
背景介绍
CD80 (also known as B7-1) is a type I membrane protein that is a member of the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, monocytes, and macrophages. CD80 is the receptor for the proteins CD28 and CTLA-4 found on the surface of T-cells. It is involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. CD80 also acts as a cellular attachment receptor for adenovirus subgroup B. (PMID: 7545666; 12015893; 16920215)
实验方案
Product Specific Protocols | |
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FC protocol for CD80 (B7-1) antibody 65083-1-Ig | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |