Anti-Human CD80 (2D10.4)

CD80 Monoclonal Antibody for FC
Cat No. 65083-1-Ig

产品说明书

CloneNo. 2D10.4

宿主/亚型

Mouse / IgG1, kappa

种属反应性

human

应用

FC

B7-1, B7 1, B7, Activation B7-1 antigen, Activation B7 1 antigen

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
规格: 

-/ -


经过测试的应用

Positive FC detected inDaudi cells
Planning an IF experiment? We recommend our CoraLite® Plus 647 conjugated versions of this antibody.

推荐稀释比

应用推荐稀释比
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

发表文章中的应用

FCSee 1 publications below

产品信息

65083-1-Ig targets CD80 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
文献引用应用FC
经测试反应性 human
文献引用反应性human
免疫原 N/A 种属同源性预测
宿主/亚型 Mouse / IgG1, kappa
抗体类别 Monoclonal
产品类型 Antibody
全称 CD80 molecule
别名 B7-1, B7 1, B7, Activation B7-1 antigen, Activation B7 1 antigen
计算分子量 33 kDa
GenBank蛋白编号BC042665
基因名称 CD80
Gene ID (NCBI) 941
RRIDAB_2918386
偶联类型 Unconjugated
形式 Liquid
纯化方式Affinity purification
储存缓冲液 PBS with 0.09% sodium azide , pH 7.3
储存条件Store at 2-8°C. Stable for one year after shipment.

背景介绍

CD80 (also known as B7-1) is a type I membrane protein that is a member of the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, monocytes, and macrophages. CD80 is the receptor for the proteins CD28 and CTLA-4 found on the surface of T-cells. It is involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. CD80 also acts as a cellular attachment receptor for adenovirus subgroup B. (PMID: 7545666; 12015893; 16920215)

实验方案

Product Specific Protocols
FC protocol for CD80 antibody 65083-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanFC

Proc Natl Acad Sci U S A

Development of a highly sensitive platform for protein-protein interaction detection and regulation of T cell function

Authors - Hideki Hayashi
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