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Anti-Human CD98/SLC3A2 Rabbit Recombinant Antibody

CD98/SLC3A2 Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241755D6

Cat no : 98190-1-RR

Print datasheet

Synonyms

CD98, SLC3A2, MDU1, Amino acid transporter heavy chain SLC3A2, 4F2 cell-surface antigen heavy chain

验证数据展示

  • FC experiment of human PBMCs using 98190-1-RR

    FC experiment of human PBMCs using 98190-1-RR

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD98 Rabbit Recombinant Antibody (98190-1-RR, Clone: 241755D6) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

  • FC experiment of human PBMCs using 98190-1-RR

    FC experiment of human PBMCs using 98190-1-RR

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD98 Rabbit Recombinant Antibody (98190-1-RR, Clone: 241755D6) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

经过测试的应用

Positive FC detected inhuman PBMCs
Planning an IHC experiment? We recommend our IHCeasy CD98/SLC3A2 Ready-To-Use IHC Kit. CD98/SLC3A2 primary antibody included.

推荐稀释比

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

98190-1-RR targets CD98/SLC3A2 in FC applications and shows reactivity with human samples.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Recombinant protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Synonyms CD98, SLC3A2, MDU1, Amino acid transporter heavy chain SLC3A2, 4F2 cell-surface antigen heavy chain
Calculated Molecular Weight68kDa
GenBank Accession NumberNM_002394.5
Gene Symbol CD98
Gene ID (NCBI) 6520
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP08195-1
Storage Buffer PBS with 0.09% sodium azide, pH 7.3.
Storage ConditionsStore at 2 - 8°C. Stable for one year after shipment.

背景介绍

CD98 is a 125-kDa type II membrane glycoprotein heterodimer composed of a 40-kDa non-glycosylated light chain (amino-acid transporter, encoded by the SLC7A5) and an 85-kDa glycosylated heavy chain (CD98hc, encoded by the SLC3A2) (PMID: 11507094). CD98hc also interacts with certain integrin b-subunits to regulate cell migration, survival, proliferation, and adhesion/polarity. CD98hc is overexpressed on the cell surface of many cancers and increased CD98hc expression is associated with the development and progression of tumors.(PMID:25084765). Molecular orientation studies have demonstrated that the C-terminal tail of human CD98 (hCD98), which contains a PDZ-binding domain, is extracellular (PMID: 18625289).

实验方案

Product Specific Protocols
FC protocol for CD98/SLC3A2 antibody 98190-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols