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验证数据展示

  • FC experiment of human PBMCs using 98190-1-RR

    FC experiment of human PBMCs using 98190-1-RR

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD98 Rabbit Recombinant Antibody (98190-1-RR, Clone: 241755D6) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

  • FC experiment of human PBMCs using 98190-1-RR

    FC experiment of human PBMCs using 98190-1-RR

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD98 Rabbit Recombinant Antibody (98190-1-RR, Clone: 241755D6) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

  • Affinity and Kinetic Characterization of 98190-1-RR

    Affinity and Kinetic Characterization of 98190-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98190-1-RR against Human CD98/SLC3A2 were performed. The affinity constant is 5.97 nM.

Anti-Human CD98/SLC3A2 Rabbit Recombinant Antibody

CD98/SLC3A2 Recombinant Antibody for FC
Cat No. 98190-1-RR

产品说明书

CloneNo. 241755D6

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

CD98, SLC3A2, MDU1, Amino acid transporter heavy chain SLC3A2, 4F2 cell-surface antigen heavy chain

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

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经过测试的应用

Positive FC detected inhuman PBMCs
Planning an IHC experiment? We recommend our IHCeasy CD98/SLC3A2 Ready-To-Use IHC Kit. CD98/SLC3A2 primary antibody included.

推荐稀释比

应用推荐稀释比
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

98190-1-RR targets CD98/SLC3A2 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
别名 CD98, SLC3A2, MDU1, Amino acid transporter heavy chain SLC3A2, 4F2 cell-surface antigen heavy chain
计算分子量68kDa
GenBank蛋白编号NM_002394.5
基因名称 CD98
Gene ID (NCBI) 6520
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP08195-1
储存缓冲液 PBS with 0.09% sodium azide , pH 7.3
储存条件Store at 2 - 8°C. Stable for one year after shipment.

背景介绍

CD98 is a 125-kDa type II membrane glycoprotein heterodimer composed of a 40-kDa non-glycosylated light chain (amino-acid transporter, encoded by the SLC7A5) and an 85-kDa glycosylated heavy chain (CD98hc, encoded by the SLC3A2) (PMID: 11507094). CD98hc also interacts with certain integrin b-subunits to regulate cell migration, survival, proliferation, and adhesion/polarity. CD98hc is overexpressed on the cell surface of many cancers and increased CD98hc expression is associated with the development and progression of tumors.(PMID:25084765). Molecular orientation studies have demonstrated that the C-terminal tail of human CD98 (hCD98), which contains a PDZ-binding domain, is extracellular (PMID: 18625289).

实验方案

Product Specific Protocols
FC protocol for CD98/SLC3A2 antibody 98190-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols