验证数据展示
产品信息
82743-1-PBS targets CHCHD3 in WB, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Applications | WB, IF/ICC, IP, Indirect ELISA Application Description |
Tested Reactivity | human, mouse |
Immunogen | CHCHD3 fusion protein Ag22579 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | coiled-coil-helix-coiled-coil-helix domain containing 3 |
Synonyms | MINOS3, MICOS complex subunit MIC19, MIC19, Coiled-coil-helix-coiled-coil-helix domain-containing protein 3 |
Calculated Molecular Weight | 227 aa, 26 kDa |
Observed Molecular Weight | 26 kDa |
GenBank Accession Number | BC014839 |
Gene Symbol | CHCHD3 |
Gene ID (NCBI) | 54927 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q9NX63 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CHCHD3, initially identified as a substrate for cAMP-dependent protein kinase (PKA), is a ubiquitous protein in the mitochondria and plays a prominent role in maintaining cristae integrity and mitochondrial function. In mitochondria, ChChd3 is predominantly localized to the inner membrane (IM), facing toward the intermembrane space (IMS), and is part of the large protein complex now called as MINOS (mitochondrial inner membrane organizing system), or MIB (mitochondrial intermembrane space bridging) CHCHD3 is highly conserved in mammals with human and mouse protein sharing ∼92% sequence similarity.