CIN85 Monoclonal antibody, PBS Only

CIN85 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

3C12D2

Cat no : 66571-1-PBS

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Synonyms

CD2 binding protein 3, CD2BP3, CIN85, GIG10, HSB 1, MIG18, SH3KBP1



产品信息

66571-1-PBS targets CIN85 in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human, mouse, rat
Immunogen CIN85 fusion protein Ag2777 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name SH3-domain kinase binding protein 1
Synonyms CD2 binding protein 3, CD2BP3, CIN85, GIG10, HSB 1, MIG18, SH3KBP1
Calculated Molecular Weight 665 aa, 73 kDa
Observed Molecular Weight 85 kDa
GenBank Accession NumberBC015806
Gene Symbol SH3KBP1/CIN85
Gene ID (NCBI) 30011
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ96B97
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CIN85 is identified as a Cbl-interacting protein of 85 kDa and belongs to adaptor/scaffold proteins. It composed of three N-terminal SH3 domains followed by a proline-rich region and a C-terminal coiled-coil region. In association with c-Cbl (Casitas B-lineage lymphoma), an E3 ubiquitin ligase. As an adaptor protein, CIN85 is involved in Cbl-dependent EGFR internalization, intracellular receptor trafficking, sorting and degradation. Moreover, through the SH3 domains and the proline-rich region, CIN85 is implicated in many protein-protein interactions and it is found to play important roles in other processes such as apoptosis, rearrangement of actin cytoskeleton, cell adhesion, immunological synapse, cell migration and invasion.