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CLN3 Monoclonal antibody, PBS Only

CLN3 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1E10A9

Cat no : 67957-1-PBS

Print datasheet

Synonyms

Batten disease protein, BATTENIN, BTS, CLN3, JNCL, Protein CLN3

验证数据展示

  • WB analysis using 67957-1-Ig (same clone as 67957-1-PBS)

    WB analysis using 67957-1-Ig (same clone as 67957-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67957-1-Ig (CLN3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated GAPDH Monoclonal antibody (HRP-60004) as loading control. This data was developed using the same antibody clone with 67957-1-PBS in a different storage buffer formulation.

产品信息

67957-1-PBS targets CLN3 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human
Immunogen CLN3 fusion protein Ag31402 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name ceroid-lipofuscinosis, neuronal 3
Synonyms Batten disease protein, BATTENIN, BTS, CLN3, JNCL, Protein CLN3
Calculated Molecular Weight 438 aa, 48 kDa
Observed Molecular Weight50 kDa
GenBank Accession NumberBC002394
Gene Symbol CLN3
Gene ID (NCBI) 1201
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ13286
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Neuronal ceroid lipofuscinosis (NCL, or Batten disease) refers to a group of lethal pediatric neurodegenerative diseases originating from mutations in one of the thus far identified 13 CLN genes (Ceroid Lipofuscinosis, Neuronal type; CLN1 to CLN14) (PMID: 25051496). CLN3 is a multi-membrane spanning protein that is involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. The CLN3 gene is located on chromosome 16p12.1and produces three mRNA splicing variants. The 438-amino-acid CLN3 protein has a calculated molecular weight of 48 kDa. It has been reported that CLN3 can be glycosylated and form homodimeric complex (PMID: 10356317; 17286803).