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CNOT3 Monoclonal antibody, PBS Only

CNOT3 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, pig , mouse, rat , rabbit

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2E12C6

Cat no : 68436-1-PBS

Print datasheet

Synonyms

CCR4 associated factor 3, CNOT3, KIAA0691, LENG2, NOT3, NOT3H

验证数据展示

  • WB analysis using 68436-1-Ig (same clone as 68436-1-PBS)

    WB analysis using 68436-1-Ig (same clone as 68436-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68436-1-Ig (CNOT3 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68436-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy CNOT3 Ready-To-Use IHC Kit. CNOT3 primary antibody included.

产品信息

68436-1-PBS targets CNOT3 in WB, Indirect ELISA applications and shows reactivity with Human, pig , mouse, rat , rabbit samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human, pig , mouse, rat , rabbit
Immunogen CNOT3 fusion protein Ag33646 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name CCR4-NOT transcription complex, subunit 3
Synonyms CCR4 associated factor 3, CNOT3, KIAA0691, LENG2, NOT3, NOT3H
Calculated Molecular Weight 120 kDa
Observed Molecular Weight120 kDa
GenBank Accession NumberBC016474
Gene Symbol CNOT3
Gene ID (NCBI) 4849
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDO75175
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The CCR4-NOT complex, the major deadenylase in mammalian cells, shortens the mRNA poly(A) tail and leads to the destabilization of mRNAs. The CCR4-NOT complex plays pivotal roles in various physiological functions, including cell apoptosis, proliferation, and metabolism [PMID:22342980]. CNOT3, belongs to the CCR4-NOT complex, has a critical role in maintaining mouse and human ESC identity as a protein complex and inhibit differentiation into the extraembryonic lineages. It is also involved in the regulation of the spindle assembly checkpoint [PMID:22342980,22367759].