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验证数据展示

  • IHC staining of human cervical cancer using 19798-1-AP (same clone as 19798-1-PBS)

    IHC staining of human cervical cancer using 19798-1-AP (same clone as 19798-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 19798-1-AP (Collagen Type VI antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19798-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 19798-1-AP (same clone as 19798-1-PBS)

    IHC staining of human lung cancer using 19798-1-AP (same clone as 19798-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 19798-1-AP (Collagen Type VI antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19798-1-PBS in a different storage buffer formulation.

  • IHC staining of human urothelial carcinoma using 19798-1-AP (same clone as 19798-1-PBS)

    IHC staining of human urothelial carcinoma using 19798-1-AP (same clone as 19798-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human urothelial carcinoma tissue slide using 19798-1-AP (Collagen Type VI antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19798-1-PBS in a different storage buffer formulation.

COL6A3 Polyclonal antibody, PBS Only

COL6A3 Polyclonal Antibody for IHC, Indirect ELISA
Cat No. 19798-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IHC, Indirect ELISA

别名

Collagen alpha 3(VI) chain, Collagen alpha-3(VI) chain, Collagen Type VI

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

19798-1-PBS targets COL6A3 in IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 collagen, type VI, alpha 3
别名 Collagen alpha 3(VI) chain, Collagen alpha-3(VI) chain, Collagen Type VI
计算分子量 344 kDa
观测分子量300 kDa
GenBank蛋白编号NM_004369
基因名称 COL6A3
Gene ID (NCBI) 1293
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDP12111
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

COL6A3 belongs to the type VI collagen family. Collagen VI acts as a cell-binding protein. It is expected to be expressed in smooth muscle. And the calculated molecular weight of COL6A3 is 343 kDa. The protein has similar expression in obese and T2DM (2 patients, and it regulates the chemotaxis and inflammation of macrophages in adipose tissue. Its expression is also related to weight gain. The expression of this protein in adipocytes is related to insulin resistance, which is believed to depend on PPAR (peroxisome proliferator-activated receptor) α-mediated adipocyte development (PMID: 25337653). Defects in COL6A3 are a cause of Bethlem myopathy (BM). Defects in COL6A3 are a cause of Ullrich congenital muscular dystrophy (UCMD) which also known as Ullrich scleroatonic muscular dystrophy. This antibody is specific to COL6A3.