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CPLX2 Polyclonal antibody, PBS Only

CPLX2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 20249-1-PBS

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Synonyms

验证数据展示

  • WB analysis of mouse brain using 20249-1-AP (same clone as 20249-1-PBS)

    WB analysis of mouse brain using 20249-1-AP (same clone as 20249-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 20249-1-AP (CPLX2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20249-1-PBS in a different storage buffer formulation.

  • IHC staining of human brain using 20249-1-AP (same clone as 20249-1-PBS)

    IHC staining of human brain using 20249-1-AP (same clone as 20249-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human brain slide using 20249-1-AP (CPLX2 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 20249-1-PBS in a different storage buffer formulation.

产品信息

20249-1-PBS targets CPLX2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen Peptide 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name complexin 2
Synonyms
Calculated Molecular Weight 15 kDa
Observed Molecular Weight 20 kDa
GenBank Accession NumberNM_006650
Gene Symbol CPLX2
Gene ID (NCBI) 10814
RRIDAB_11232598
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ6PUV4
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Neuronal specific complexin 1 (CPLX1) has inhibitory and stimulatory effects on exocytosis by clamping trans-SNARE complexes in a prefusion state and promoting conformational changes to facilitate membrane fusion following cell stimulation. Complexin2 (CPLX2) is a pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals, it is downregulated in schizophrenic patients suffering from depression, animal models of depression and neurological disorders such as Huntington's disease in which depression is a major symptom. This antibody is expected to specifically recogize CPLX2 but not other complexins.