- Featured Product
- KD/KO Validated
CRBN Monoclonal antibody
CRBN Monoclonal Antibody for ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human, pig, mouse
Applications
ELISA and More (1)
Conjugate
Unconjugated
CloneNo.
2A9D11
验证数据展示
发表文章中的应用
| IHC | See 1 publications below |
产品信息
66336-1-Ig targets CRBN in IHC, ELISA applications and shows reactivity with human, pig, mouse samples.
| Tested Applications | ELISA Application Description |
| Cited Applications | IHC |
| Tested Reactivity | human, pig, mouse |
| Cited Reactivity | human |
| Immunogen | CRBN fusion protein Ag17166 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | cereblon |
| Synonyms | cereblon, CRBN, MRT2A, Protein cereblon |
| Calculated Molecular Weight | 442 aa, 51 kDa |
| Observed Molecular Weight | 51-60 kDa |
| GenBank Accession Number | BC017419 |
| Gene Symbol | CRBN |
| Gene ID (NCBI) | 51185 |
| RRID | AB_2881716 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q96SW2 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
CRBN plays an important role in assembly and surface expression of functional BK(Ca) channels. The mutation of human cereblon gene (CRBN) is related with mild mental retardation, and causes ARNSID (nonsyndromal intellectual disability) by distubing the developmental regulation of BK(Ca) in brain regions that are critical for memory and learning. CRBN is also identified as important thalidomide-binding protein for limb outgrowth in zebrafish and chicks. It can be detected a band above 51 kDa (maybe 55 kDa) in HT22 cells(PMID: 21232561).
发表文章
| Species | Application | Title |
|---|---|---|
Front Oncol Prediction Model for Cereblon Expression in Bone Marrow Plasma Cells Based on Blood Markers in Multiple Myeloma Patients. |