验证数据展示
Planning an IF experiment? We recommend our CoraLite® Plus 488 conjugated versions of this antibody.
发表文章中的应用
| IHC | See 1 publications below |
产品信息
66336-1-Ig targets CRBN in IHC, ELISA applications and shows reactivity with human, pig, mouse samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | IHC |
| 经测试反应性 | human, pig, mouse |
| 文献引用反应性 | human |
| 免疫原 | CRBN fusion protein Ag17166 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | cereblon |
| 别名 | cereblon, CRBN, MRT2A, Protein cereblon |
| 计算分子量 | 442 aa, 51 kDa |
| 观测分子量 | 51-60 kDa |
| GenBank蛋白编号 | BC017419 |
| 基因名称 | CRBN |
| Gene ID (NCBI) | 51185 |
| RRID | AB_2881716 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q96SW2 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
CRBN plays an important role in assembly and surface expression of functional BK(Ca) channels. The mutation of human cereblon gene (CRBN) is related with mild mental retardation, and causes ARNSID (nonsyndromal intellectual disability) by distubing the developmental regulation of BK(Ca) in brain regions that are critical for memory and learning. CRBN is also identified as important thalidomide-binding protein for limb outgrowth in zebrafish and chicks. It can be detected a band above 51 kDa (maybe 55 kDa) in HT22 cells(PMID: 21232561).