验证数据展示
产品信息
67035-1-PBS targets CRK in WB, ELISA applications and shows reactivity with Human, mouse, rat samples.
Tested Applications | WB, ELISA Application Description |
Tested Reactivity | Human, mouse, rat |
Immunogen | CRK fusion protein Ag28793 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | v-crk sarcoma virus CT10 oncogene homolog (avian) |
Synonyms | Adapter molecule crk, CRK, CRKII, p38, Proto oncogene c Crk |
Calculated Molecular Weight | 34 kDa |
Observed Molecular Weight | 34 kDa |
GenBank Accession Number | BC008506 |
Gene Symbol | CRK |
Gene ID (NCBI) | 1398 |
RRID | AB_2882350 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P46108 |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CRK is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. CRK has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.