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CRK Monoclonal antibody, PBS Only

CRK Monoclonal Antibody for WB, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse, rat

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

2B7E1

Cat no : 67035-1-PBS

Print datasheet

Synonyms

Adapter molecule crk, CRK, CRKII, p38, Proto oncogene c Crk

验证数据展示

  • WB analysis of HEK-293 using 67035-1-Ig (same clone as 67035-1-PBS)

    WB analysis of HEK-293 using 67035-1-Ig (same clone as 67035-1-PBS)

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 67035-1-Ig (CRK antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67035-1-PBS in a different storage buffer formulation.

产品信息

67035-1-PBS targets CRK in WB, ELISA applications and shows reactivity with Human, mouse, rat samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity Human, mouse, rat
Immunogen CRK fusion protein Ag28793 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name v-crk sarcoma virus CT10 oncogene homolog (avian)
Synonyms Adapter molecule crk, CRK, CRKII, p38, Proto oncogene c Crk
Calculated Molecular Weight 34 kDa
Observed Molecular Weight 34 kDa
GenBank Accession NumberBC008506
Gene Symbol CRK
Gene ID (NCBI) 1398
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP46108
Storage Buffer PBS only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CRK is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. CRK has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.