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CUEDC2 Polyclonal antibody, PBS Only

CUEDC2 Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, IF/ICC, IP, Indirect ELISA

Conjugate

Unconjugated

Cat no : 20123-1-PBS

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Synonyms

验证数据展示

  • WB analysis using 20123-1-AP (same clone as 20123-1-PBS)

    WB analysis using 20123-1-AP (same clone as 20123-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20123-1-AP (CUEDC2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20123-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse brain using 20123-1-AP (same clone as 20123-1-PBS)

    IP experiment of mouse brain using 20123-1-AP (same clone as 20123-1-PBS)

    IP result of anti-CUEDC2 (IP:20123-1-AP, 4ug; Detection:20123-1-AP 1:500) with mouse brain tissue lysate 4000ug. This data was developed using the same antibody clone with 20123-1-PBS in a different storage buffer formulation.

  • IHC staining of human ovary tumor using 20123-1-AP (same clone as 20123-1-PBS)

    IHC staining of human ovary tumor using 20123-1-AP (same clone as 20123-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 20123-1-AP (CUEDC2 antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20123-1-PBS in a different storage buffer formulation.

  • IHC staining of human ovary tumor using 20123-1-AP (same clone as 20123-1-PBS)

    IHC staining of human ovary tumor using 20123-1-AP (same clone as 20123-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 20123-1-AP (CUEDC2 antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20123-1-PBS in a different storage buffer formulation.

  • IF Staining of HeLa using 20123-1-AP (same clone as 20123-1-PBS)

    IF Staining of HeLa using 20123-1-AP (same clone as 20123-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed HeLa cells using CUEDC2 antibody (20123-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 20123-1-PBS in a different storage buffer formulation.

产品信息

20123-1-PBS targets CUEDC2 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, IHC, IF/ICC, IP, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen CUEDC2 fusion protein Ag13847 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name CUE domain containing 2
Synonyms
Calculated Molecular Weight 287 aa, 32 kDa
Observed Molecular Weight 32 kDa
GenBank Accession NumberBC000262
Gene Symbol CUEDC2
Gene ID (NCBI) 79004
RRIDAB_10638318
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9H467
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CUE domain-containing 2 (CUEDC2) is a ubiquitin-binding motif-containing protein involved in the regulation of the cell cycle, inflammation, and tumorigenesis. It is ubiquitously expressed in human tissues and organs, not only highly expressed in the normal brain, heart and testis, but also some kinds of cancers, such as breast, ovarian and kidney cancers. CUEDC2 could act as an adaptor protein to target IκB kinase (IKK) for dephosphorylation and inactivation by recruiting protein phosphatase (PP1), and thus repressed activation of the transcription factor NF-κB. Moreover, CUEDC2, is a key factor in endocrine resistance in breast cancer.