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Anti-Human CXCR4/CD184 Rabbit Recombinant Antibody, PBS Only

CXCR4/CD184 Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241735F8

Cat no : 98175-1-PBS

Print datasheet

Synonyms

CXCR4, CXCR 4, CXC R4, C-X-C chemokine receptor type 4, CD184

验证数据展示

  • FC experiment of human PBMCs using 98175-1-RR (same clone as 98175-1-PBS)

    FC experiment of human PBMCs using 98175-1-RR (same clone as 98175-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CXCR4/CD184 Rabbit Recombinant Antibody (98175-1-RR, Clone: 241735F8),or Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Human CD19. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98175-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98175-1-RR (same clone as 98175-1-PBS)

    FC experiment of human PBMCs using 98175-1-RR (same clone as 98175-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CXCR4/CD184 Rabbit Recombinant Antibody (98175-1-RR, Clone:241735F8)(red) or Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98175-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy CXCR4 Ready-To-Use IHC Kit. CXCR4 primary antibody included.

产品信息

98175-1-PBS targets CXCR4/CD184 in FC applications and shows reactivity with human samples.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Recombinant Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name chemokine (C-X-C motif) receptor 4
Synonyms CXCR4, CXCR 4, CXC R4, C-X-C chemokine receptor type 4, CD184
Calculated Molecular Weight 352 aa, 40 kDa
GenBank Accession NumberBC020968
Gene Symbol CXCR4
Gene ID (NCBI) 7852
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP61073
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

C-X-C chemokine receptor type 4 (CXCR4, also known as CD184) is a widely expressed G protein-coupled seven-transmembrane receptor. CXCL12/SDF-1 is the biological ligand for CXCR4. The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription (PMID: 20484021). CXCR4 also functions as a coreceptor for HIV-1 entry (PMID: 9427609).