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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 68576-1-Ig (same clone as 68576-1-PBS)

    WB analysis using 68576-1-Ig (same clone as 68576-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68576-1-Ig (CYP46A1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68576-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 68576-1-Ig (same clone as 68576-1-PBS)

    IHC staining of mouse brain using 68576-1-Ig (same clone as 68576-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 68576-1-Ig (CYP46A1 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68576-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 68576-1-Ig (same clone as 68576-1-PBS)

    IHC staining of mouse brain using 68576-1-Ig (same clone as 68576-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 68576-1-Ig (CYP46A1 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68576-1-PBS in a different storage buffer formulation.

CYP46A1 Monoclonal antibody, PBS Only

CYP46A1 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 68576-1-PBS

产品说明书

CloneNo. 1E10D3

宿主/亚型

Mouse / IgG2b

种属反应性

Human, Mouse, Rat, Rabbit, Pig

应用

WB, IHC, Indirect ELISA

别名

CH24H, Cholesterol 24 hydroxylase, CP46, CYP46, CYP46A1, Cytochrome P450 46A1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

68576-1-PBS targets CYP46A1 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat, Rabbit, Pig samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 Human, Mouse, Rat, Rabbit, Pig
免疫原 CYP46A1 fusion protein Ag16786 种属同源性预测
宿主/亚型 Mouse / IgG2b
抗体类别 Monoclonal
产品类型 Antibody
全称 cytochrome P450, family 46, subfamily A, polypeptide 1
别名 CH24H, Cholesterol 24 hydroxylase, CP46, CYP46, CYP46A1, Cytochrome P450 46A1
计算分子量 500 aa, 57 kDa
观测分子量 57 kDa
GenBank蛋白编号BC022539
基因名称 CYP46A1
Gene ID (NCBI) 10858
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ9Y6A2
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Cytochrome P450 46A1 (CYP46A1), also named as CYP46, P450 46A1, CH24H and Cholesterol 24-hydroxylase, belongs to the cytochrome P450 family. CYP46A1 is a central nervous system-specific enzyme, and can freely cross the blood-brain barrier and be degraded in the liver. It is involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. CYP46A1 is significantly upregulated in hepatic lymphomyeloid cells compared with ESCs.(PMID:20039312)