CYP51A1 Recombinant antibody

CYP51A1 Uni-rAbTM Recombinant Antibody for WB, ELISA
Cat No. 84705-4-RR

产品说明书

CloneNo. 242166G9

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, ELISA

Cytochrome P450 14DM, CYPLI, CYPL1, CYP51, CP51

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive WB detected inHeLa cells, HepG2 cells, HuH-7 cells, HEK-293 cells, RAW 264.7 cells, mouse testis tissue, rat liver tissue

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:5000-1:50000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

84705-4-RR targets CYP51A1 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 CYP51A1 fusion protein Ag4235 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 cytochrome P450, family 51, subfamily A, polypeptide 1
别名 Cytochrome P450 14DM, CYPLI, CYPL1, CYP51, CP51
计算分子量 509 aa, 57 kDa
观测分子量56 kDa
GenBank蛋白编号BC032322
基因名称 CYP51A1
Gene ID (NCBI) 1595
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ16850
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Lanosterol 14-alpha demethylase (cytochrome P450(51), CYP51A1) belongs to the evolutionarily conserved family of cytochrome P450 and catalyzes one of the key steps in cholesterol biosynthesis. CYP51A1 protein is targeted for degradation when exposed to nitric oxide generated under inflammatory conditions by NOS2 or released from NO donor compounds (PMID: 28830911). CYP51A1 is a prognostic marker in certain cancers, including Cervical squamous cell carcinoma, Head and neck squamous cell carcinoma, Kidney chromophobe, and Kidney renal clear cell carcinoma (PMID: 24711211).

实验方案

Product Specific Protocols
WB protocol for CYP51A1 antibody 84705-4-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols
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