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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 84705-4-RR (same clone as 84705-4-PBS)

    WB analysis using 84705-4-RR (same clone as 84705-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84705-4-RR (CYP51A1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84705-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84705-4-RR

    Affinity and Kinetic Characterization of 84705-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84705-4-RR against Human CYP51A1 were performed. The affinity constant is below 1 pM.

CYP51A1 Recombinant antibody, PBS Only

CYP51A1 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 84705-4-PBS

产品说明书

CloneNo. 242166G9

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, Indirect ELISA

别名

Cytochrome P450 14DM, CYPLI, CYPL1, CYP51, CP51

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

84705-4-PBS targets CYP51A1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 CYP51A1 fusion protein Ag4235 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 cytochrome P450, family 51, subfamily A, polypeptide 1
别名 Cytochrome P450 14DM, CYPLI, CYPL1, CYP51, CP51
计算分子量 509 aa, 57 kDa
观测分子量56 kDa
GenBank蛋白编号BC032322
基因名称 CYP51A1
Gene ID (NCBI) 1595
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ16850
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Lanosterol 14-alpha demethylase (cytochrome P450(51), CYP51A1) belongs to the evolutionarily conserved family of cytochrome P450 and catalyzes one of the key steps in cholesterol biosynthesis. CYP51A1 protein is targeted for degradation when exposed to nitric oxide generated under inflammatory conditions by NOS2 or released from NO donor compounds (PMID: 28830911). CYP51A1 is a prognostic marker in certain cancers, including Cervical squamous cell carcinoma, Head and neck squamous cell carcinoma, Kidney chromophobe, and Kidney renal clear cell carcinoma (PMID: 24711211).