• Featured Product
  • KD/KO验证

Caspase 1 Recombinant antibody

Caspase 1 Uni-rAbTM Recombinant Antibody for WB, ELISA
Cat No. 81482-1-RR

产品说明书

CloneNo. 1O18

宿主/亚型

Rabbit / IgG

种属反应性

human and More (2)

应用

WB, ELISA and More (2)

CASP1, Caspase1, Caspase-1, CASP-1, CASP 1

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
CoraLite® Plus 750
规格: 

-/ -


经过测试的应用

Positive WB detected inRaji cells, THP-1 cells, U-937 cells

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:5000-1:50000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

81482-1-RR targets Caspase 1 in WB, IHC, IF, ELISA applications and shows reactivity with human samples.

经测试应用 WB, ELISA Application Description
文献引用应用WB, IHC, IF
经测试反应性 human
文献引用反应性human, mouse, rat
免疫原 Caspase 1 fusion protein Ag11143 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
别名 CASP1, Caspase1, Caspase-1, CASP-1, CASP 1
计算分子量 404 aa, 45 kDa
观测分子量30 kDa, 35 kDa, 43-45 kDa
GenBank蛋白编号BC062327
基因名称 Caspase 1
Gene ID (NCBI) 834
RRIDAB_2935555
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP29466
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products (PMID:21804020). It has 5 isoforms produced by alternative splicing. 81482-1-RR can recognize the splicing isoforms of caspase 1.

实验方案

Product Specific Protocols
WB protocol for Caspase 1 antibody 81482-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB

Adv Sci (Weinh)

Scutellarin Rescued Mitochondrial Damage through Ameliorating Mitochondrial Glucose Oxidation via the Pdk-Pdc Axis

Authors - Ning Sheng
ratWB,IF

Phytomedicine

Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells

Authors - Dong Wang
mouseWB

Int Immunopharmacol

Triggering receptor expressed on myeloid cells-1 aggravates obliterative bronchiolitis via enhancing the proinflammatory phenotype of macrophages

Authors - Junhao Wan
mouseWB

Antioxidants (Basel)

Bisdemethoxycurcumin Alleviates Dextran Sodium Sulfate-Induced Colitis via Inhibiting NLRP3 Inflammasome Activation and Modulating the Gut Microbiota in Mice

Authors - Jingfei Zhang
ratWB

PLoS One

Forsythoside B alleviates cerebral ischemia-reperfusion injury via inhibiting NLRP3 inflammasome mediated by SIRT1 activation

Authors - Qiaoyu Li
mouseWB

Biochem Biophys Res Commun

Uric acid-lowering effect of harpagoside and its protective effect against hyperuricemia-induced renal injury in mice

Authors - Qiong Fu
Loading...