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验证数据展示

  • IF Staining of mouse liver using 84752-1-RR (same clone as 84752-1-PBS)

    IF Staining of mouse liver using 84752-1-RR (same clone as 84752-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse liver tissue using Caspase 1 antibody (84752-1-RR, Clone: 241966A3 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84752-1-PBS in a different storage buffer formulation.

Caspase 1 Recombinant antibody, PBS Only

Caspase 1 Uni-rAbTM Recombinant Antibody for IF-P, Indirect ELISA
Cat No. 84752-1-PBS

产品说明书

CloneNo. 241966A3

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IF-P, Indirect ELISA

别名

CASP1, Caspase1, Caspase-1, CASP-1, CASP 1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

84752-1-PBS targets Caspase 1 in IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IF-P, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
别名 CASP1, Caspase1, Caspase-1, CASP-1, CASP 1
计算分子量 404 aa, 45 kDa
GenBank蛋白编号BC062327
基因名称 Caspase 1
Gene ID (NCBI) 834
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP29466
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products (PMID:21804020). It has 5 isoforms produced by alternative splicing.