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Caspase 1 Recombinant antibody, PBS Only

Caspase 1 Uni-rAbTM Recombinant Antibody for IF-P, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

IF-P, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241966A3

Cat no : 84752-1-PBS

Print datasheet

Synonyms

CASP1, Caspase1, Caspase-1, CASP-1, CASP 1

验证数据展示

  • IF Staining of mouse liver using 84752-1-RR (same clone as 84752-1-PBS)

    IF Staining of mouse liver using 84752-1-RR (same clone as 84752-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse liver tissue using Caspase 1 antibody (84752-1-RR, Clone: 241966A3 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84752-1-PBS in a different storage buffer formulation.

产品信息

84752-1-PBS targets Caspase 1 in IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications IF-P, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen Peptide 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Synonyms CASP1, Caspase1, Caspase-1, CASP-1, CASP 1
Calculated Molecular Weight 404 aa, 45 kDa
GenBank Accession NumberBC062327
Gene Symbol Caspase 1
Gene ID (NCBI) 834
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP29466
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products (PMID:21804020). It has 5 isoforms produced by alternative splicing.