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Claudin 18 Monoclonal antibody, PBS Only

Claudin 18 Monoclonal Antibody for IP, IHC, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human, mouse

Applications

IP, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

5G7F2

Cat no : 66167-1-PBS

Print datasheet

Synonyms

claudin 18, CLDN18, SFTA5, SFTPJ

验证数据展示

  • IP experiment of mouse stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    IP experiment of mouse stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    IP result of anti-Claudin 18 (IP:66167-1-Ig, 3ug; Detection:66167-1-Ig 1:300) with mouse stomach tissue lysate 4000ug. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

  • IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:1000. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with Claudin 18 antibody included
  • IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:1000. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with Claudin 18 antibody included
Planning an IHC experiment? We recommend our IHCeasy Claudin 18 Ready-To-Use IHC Kit. Claudin 18 primary antibody included.

产品信息

66167-1-PBS targets Claudin 18 in IP, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications IP, IHC, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen Claudin 18 fusion protein Ag15517 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name claudin 18
Synonyms claudin 18, CLDN18, SFTA5, SFTPJ
Calculated Molecular Weight 261 aa, 28 kDa
Observed Molecular Weight 29 kDa
GenBank Accession NumberBC146668
Gene Symbol CLDN18
Gene ID (NCBI) 51208
RRIDAB_2881563
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP56856
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Claudin 18 (CLDN18) belongs to the large claudin family of proteins, which are tetraspan transmembrane proteins of tight junctions (PMID: 11585919; 18036336). Claudins exhibit specific patterns of expression in different tissues (PMID: 15447685). CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific (PMID: 11585919; 21832145). Altered CLDN18 expression has been reported in various human malignancies, including gastric cancer, lung adenocarcinoma, and pancreatic neoplasm (PMID: 17459057; 22076167; 21832145). This antibody can recognize both CLDN18.1 and CLDN18.2.