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验证数据展示

  • IHC staining of human pancreas cancer using 66167-1-Ig (same clone as 66167-1-PBS)

    IHC staining of human pancreas cancer using 66167-1-Ig (same clone as 66167-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 66167-1-Ig (Claudin 18 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with Claudin 18 antibody included
  • IP experiment of mouse stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    IP experiment of mouse stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    IP result of anti-Claudin 18 (IP:66167-1-Ig, 3ug; Detection:66167-1-Ig 1:300) with mouse stomach tissue lysate 4000ug. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

  • IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:1000. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with Claudin 18 antibody included
  • IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:1000. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with Claudin 18 antibody included

Claudin 18 Monoclonal antibody, PBS Only

Claudin 18 Monoclonal Antibody for IHC, IP, Indirect ELISA
Cat No. 66167-1-PBS

产品说明书

CloneNo. 5G7F2

宿主/亚型

Mouse / IgG2a

种属反应性

human, mouse

应用

IHC, IP, Indirect ELISA

别名

UNQ778/PRO1572, CLDN18, Claudin-18, Claudin18, 5G7F2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy Claudin 18 Ready-To-Use IHC Kit. Claudin 18 primary antibody included.

产品信息

66167-1-PBS targets Claudin 18 in IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 Claudin 18 fusion protein Ag15517 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 claudin 18
别名 UNQ778/PRO1572, CLDN18, Claudin-18, Claudin18, 5G7F2
计算分子量 261 aa, 28 kDa
观测分子量 29 kDa
GenBank蛋白编号BC146668
基因名称 CLDN18
Gene ID (NCBI) 51208
RRIDAB_2881563
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP56856
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Claudin 18 (CLDN18) belongs to the large claudin family of proteins, which are tetraspan transmembrane proteins of tight junctions (PMID: 11585919; 18036336). Claudins exhibit specific patterns of expression in different tissues (PMID: 15447685). CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific (PMID: 11585919; 21832145). Altered CLDN18 expression has been reported in various human malignancies, including gastric cancer, lung adenocarcinoma, and pancreatic neoplasm (PMID: 17459057; 22076167; 21832145). This antibody can recognize both CLDN18.1 and CLDN18.2.