验证数据展示
产品信息
66812-1-PBS targets Cystatin B in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
Tested Applications | WB, IHC, IF/ICC, Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | Cystatin B fusion protein Ag21291 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | cystatin B (stefin B) |
Synonyms | CSTB, Cystatin-B, CST6, CPI-B, CPI B |
Calculated Molecular Weight | 11 kDa |
Observed Molecular Weight | 11-14 kDa |
GenBank Accession Number | BC003370 |
Gene Symbol | Cystatin B |
Gene ID (NCBI) | 1476 |
RRID | AB_2882155 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | P04080 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Cystatin B (CSTB), a member of the cystatin superfamily protein, is a stefin that functions as an intracellular thiol protease inhibitor and has been thought to play a role in protecting against the proteases leaking from lysosomes. CSTB plays various functions in a variety of diseases, including epithelial ovarian cancer, colon cancer, and myoclonus epilepsy. Evidence indicates that mutations in CSTB are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies.