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验证数据展示

  • WB analysis of K-562 using 66754-1-Ig (same clone as 66754-1-PBS)

    WB analysis of K-562 using 66754-1-Ig (same clone as 66754-1-PBS)

    K-562 cells were subjected to SDS PAGE followed by western blot with 66754-1-Ig (DR6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66754-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 66754-1-Ig (same clone as 66754-1-PBS)

    IF Staining of HepG2 using 66754-1-Ig (same clone as 66754-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using DR6 antibody (66754-1-Ig, Clone: 3C2D10 ) at dilution of 1:800 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66754-1-PBS in a different storage buffer formulation.

TNFRSF21 Monoclonal antibody, PBS Only

TNFRSF21 Monoclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 66754-1-PBS

产品说明书

CloneNo. 3C2D10

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

DR6, UNQ437/PRO868, Death receptor 6, CD358, 3C2D10

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 
100 μg

¥5800/ 100 μg

浓度: 1000 μg/ml

库存：现货

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产品信息

66754-1-PBS targets TNFRSF21 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原 TNFRSF21 fusion protein Ag14327 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 tumor necrosis factor receptor superfamily, member 21
别名 DR6, UNQ437/PRO868, Death receptor 6, CD358, 3C2D10
计算分子量 655 aa, 72 kDa
观测分子量 69 kDa
GenBank蛋白编号BC021572
基因名称 DR6
Gene ID (NCBI) 27242
RRIDAB_2882100
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDO75509
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TNFRSF21 (also known as DR6 or CD358) is an orphan receptor of the tumor necrosis factor (TNF) receptor superfamily. It controls cell death and differentiation in a cell-autonomous manner in different cell types including neurons, oligodendrocytes, endothelial cells, and immune cells (PMID: 29459438). DR6 has been shown to activate NF-κB and JNK, and induce cell apoptosis (PMID: 9714541). DR6 interacts with TRADD, which is known to mediate signal transduction of TNF receptors. It has been reported that APP binds DR6 to trigger axon pruning and neuron death via distinct caspases, indicating that DR6 might be involved in Alzheimer's disease (PMID: 19225519).