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TNFRSF21 Monoclonal antibody, PBS Only

TNFRSF21 Monoclonal Antibody for WB, IF/ICC, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

WB, IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

3C2D10

Cat no : 66754-1-PBS

Print datasheet

Synonyms

DR6, UNQ437/PRO868, Death receptor 6, CD358, 3C2D10

验证数据展示

  • WB analysis of K-562 using 66754-1-Ig (same clone as 66754-1-PBS)

    WB analysis of K-562 using 66754-1-Ig (same clone as 66754-1-PBS)

    K-562 cells were subjected to SDS PAGE followed by western blot with 66754-1-Ig (DR6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66754-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 66754-1-Ig (same clone as 66754-1-PBS)

    IF Staining of HepG2 using 66754-1-Ig (same clone as 66754-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using DR6 antibody (66754-1-Ig, Clone: 3C2D10 ) at dilution of 1:800 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66754-1-PBS in a different storage buffer formulation.

产品信息

66754-1-PBS targets TNFRSF21 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, IF/ICC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen TNFRSF21 fusion protein Ag14327 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name tumor necrosis factor receptor superfamily, member 21
Synonyms DR6, UNQ437/PRO868, Death receptor 6, CD358, 3C2D10
Calculated Molecular Weight 655 aa, 72 kDa
Observed Molecular Weight 69 kDa
GenBank Accession NumberBC021572
Gene Symbol DR6
Gene ID (NCBI) 27242
RRIDAB_2882100
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDO75509
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TNFRSF21 (also known as DR6 or CD358) is an orphan receptor of the tumor necrosis factor (TNF) receptor superfamily. It controls cell death and differentiation in a cell-autonomous manner in different cell types including neurons, oligodendrocytes, endothelial cells, and immune cells (PMID: 29459438). DR6 has been shown to activate NF-κB and JNK, and induce cell apoptosis (PMID: 9714541). DR6 interacts with TRADD, which is known to mediate signal transduction of TNF receptors. It has been reported that APP binds DR6 to trigger axon pruning and neuron death via distinct caspases, indicating that DR6 might be involved in Alzheimer's disease (PMID: 19225519).