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DSG1 Recombinant antibody, PBS Only

DSG1 Uni-rAbTM Recombinant Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, rat

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241093G11

Cat no : 84053-6-PBS

Print datasheet

Synonyms

Desmosomal glycoprotein 1, Desmoglein-1, desmoglein 1, CDHF4, Cadherin family member 4

验证数据展示

  • WB analysis using 84053-6-RR (same clone as 84053-6-PBS)

    WB analysis using 84053-6-RR (same clone as 84053-6-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84053-6-RR (DSG1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84053-6-PBS in a different storage buffer formulation.

  • IHC staining of mouse skin using 84053-6-RR (same clone as 84053-6-PBS)

    IHC staining of mouse skin using 84053-6-RR (same clone as 84053-6-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 84053-6-RR (DSG1 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84053-6-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with DSG1 antibody included
  • IHC staining of mouse skin using 84053-6-RR (same clone as 84053-6-PBS)

    IHC staining of mouse skin using 84053-6-RR (same clone as 84053-6-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 84053-6-RR (DSG1 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84053-6-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with DSG1 antibody included
  • Affinity and Kinetic Characterization of 84053-6-RR

    Affinity and Kinetic Characterization of 84053-6-RR

    Biolayer interferometry (BLl) kinetic assays of 84053-6-RR against Human DSG1 were performed. The affinity constant is 71.2 pM.

Planning an IHC experiment? We recommend our IHCeasy DSG1 Ready-To-Use IHC Kit. DSG1 primary antibody included.

产品信息

84053-6-PBS targets DSG1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, rat samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human, rat
Immunogen DSG1 fusion protein Ag20184 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name desmoglein 1
Synonyms Desmosomal glycoprotein 1, Desmoglein-1, desmoglein 1, CDHF4, Cadherin family member 4
Calculated Molecular Weight 1049 aa, 114 kDa
Observed Molecular Weight160 kDa
GenBank Accession NumberBC153001
Gene Symbol DSG1
Gene ID (NCBI) 1828
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ02413
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmosomal cadherins, consisting of four desmogleins (DSG1-4) and three desmocollins (DSC1-3) in humans, mediate adhesion through calcium-dependent homophilic/heterophilic interactions. DSG1 is a single-pass transmembrane glycoprotein highly expressed in the epidermis and localized primarily within the suprabasal epithelial layers (PMID: 16286477; 24220297). DSG1 mediates intercellular adhesion and is crucial in maintaining epidermal integrity and barrier function (PMID: 23974871). It is also involved in epithelial cell differentiation (PMID: 23524961). Mutations in the DSG1 gene can cause the autosomal dominant disorder to striate palmoplantar keratoderma and a syndrome featuring severe dermatitis, multiple allergies, and metabolic wasting (SAM syndrome) (PMID: 29315490; 23974871).