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验证数据展示

  • WB analysis using 84053-6-RR (same clone as 84053-6-PBS)

    WB analysis using 84053-6-RR (same clone as 84053-6-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84053-6-RR (DSG1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84053-6-PBS in a different storage buffer formulation.

  • IHC staining of mouse skin using 84053-6-RR (same clone as 84053-6-PBS)

    IHC staining of mouse skin using 84053-6-RR (same clone as 84053-6-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 84053-6-RR (DSG1 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84053-6-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with DSG1 antibody included
  • IHC staining of mouse skin using 84053-6-RR (same clone as 84053-6-PBS)

    IHC staining of mouse skin using 84053-6-RR (same clone as 84053-6-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 84053-6-RR (DSG1 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84053-6-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with DSG1 antibody included
  • Affinity and Kinetic Characterization of 84053-6-RR

    Affinity and Kinetic Characterization of 84053-6-RR

    Biolayer interferometry (BLl) kinetic assays of 84053-6-RR against Human DSG1 were performed. The affinity constant is 71.2 pM.

DSG1 Recombinant antibody, PBS Only

DSG1 Uni-rAbTM Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 84053-6-PBS

产品说明书

CloneNo. 241093G11

宿主/亚型

Rabbit / IgG

种属反应性

human, rat

应用

WB, IHC, Indirect ELISA

别名

Desmosomal glycoprotein 1, Desmoglein-1, desmoglein 1, CDHF4, Cadherin family member 4

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy DSG1 Ready-To-Use IHC Kit. DSG1 primary antibody included.

产品信息

84053-6-PBS targets DSG1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, rat
免疫原 DSG1 fusion protein Ag20184 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 desmoglein 1
别名 Desmosomal glycoprotein 1, Desmoglein-1, desmoglein 1, CDHF4, Cadherin family member 4
计算分子量 1049 aa, 114 kDa
观测分子量160 kDa
GenBank蛋白编号BC153001
基因名称 DSG1
Gene ID (NCBI) 1828
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ02413
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmosomal cadherins, consisting of four desmogleins (DSG1-4) and three desmocollins (DSC1-3) in humans, mediate adhesion through calcium-dependent homophilic/heterophilic interactions. DSG1 is a single-pass transmembrane glycoprotein highly expressed in the epidermis and localized primarily within the suprabasal epithelial layers (PMID: 16286477; 24220297). DSG1 mediates intercellular adhesion and is crucial in maintaining epidermal integrity and barrier function (PMID: 23974871). It is also involved in epithelial cell differentiation (PMID: 23524961). Mutations in the DSG1 gene can cause the autosomal dominant disorder to striate palmoplantar keratoderma and a syndrome featuring severe dermatitis, multiple allergies, and metabolic wasting (SAM syndrome) (PMID: 29315490; 23974871).