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验证数据展示

  • WB analysis using 68515-1-Ig (same clone as 68515-1-PBS)

    WB analysis using 68515-1-Ig (same clone as 68515-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68515-1-Ig (DSG2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68515-1-PBS in a different storage buffer formulation.

  • Cytometric bead array standard curve of MP51241-1

    Cytometric bead array standard curve of MP51241-1

    Cytometric bead array standard curve of MP51241-1, DSG2 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 68515-1-PBS. Detection antibody: 68515-2-PBS. Standard:Ag20633. Range: 0.391-100 ng/mL.

DSG2 Monoclonal antibody, PBS Only (Capture)

DSG2 Monoclonal Antibody for WB, Cytometric bead array, Indirect ELISA
Cat No. 68515-1-PBS

产品说明书

CloneNo. 1B8C3

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

WB, Cytometric bead array, Indirect ELISA

别名

Desmoglein-2, Desmoglein 2, CDHF5, Cadherin family member 5, ARVD10

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy DSG2 Ready-To-Use IHC Kit. DSG2 primary antibody included.

产品信息

68515-1-PBS targets DSG2 as part of a matched antibody pair:

MP51241-1: 68515-1-PBS capture and 68515-2-PBS detection (validated in Cytometric bead array)

Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

经测试应用 WB, Cytometric bead array, Indirect ELISA Application Description
经测试反应性 human
免疫原 DSG2 fusion protein Ag20633 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 desmoglein 2
别名 Desmoglein-2, Desmoglein 2, CDHF5, Cadherin family member 5, ARVD10
计算分子量 1118 aa, 122 kDa
观测分子量145-150 kDa
GenBank蛋白编号BC099655
基因名称 DSG2
Gene ID (NCBI) 1829
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ14126
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmosomal cadherins, consisting of four desmogleins (DSG1-4) and three desmocollins (DSC1-3) in humans, mediate adhesion through calcium-dependent homophilic/heterophilic interactions. DSG2 is a single-pass transmembrane glycoprotein that is widely expressed in epithelial and non-epithelial tissues, such as the intestine, epidermis, testis, and heart (PMID:21715983). Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10), and genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB).