验证数据展示
发表文章中的应用
| WB | See 4 publications below |
| IHC | See 1 publications below |
产品信息
10433-1-AP targets DUSP6 in WB, IHC, ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IHC |
| 经测试反应性 | human |
| 文献引用反应性 | human, mouse, rat |
| 免疫原 | DUSP6 fusion protein Ag0705 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | dual specificity phosphatase 6 |
| 别名 | dual specificity phosphatase 6, DUSP6, MAP kinase phosphatase 3, MKP 3, MKP3, PYST1 |
| 计算分子量 | 42 kDa |
| GenBank蛋白编号 | BC003562 |
| 基因名称 | DUSP6 |
| Gene ID (NCBI) | 1848 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q16828 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Dual specificity phosphatase 6 (DUSP6) is a member of the family of mitogen-activated protein kinase (MAPK) phosphatases, which dephosphorylate and inactivate MAPK (PMID: 9858808). The MAPK pathway is an important signal transduction system that serves cellular processes, such as proliferation, differentiation, migration, and apoptosis. DUSP6 resides at chromosome location 12q22-23, which is one of the candidate loci for susceptibility to bipolar disorder and which encodes a phosphatase selective for extracellular signal-regulated kinase (ERK) (PMID: 9205128). DUSP6 inactivates extracellular signal-regulated kinase (ERK), and can act in tumor suppressive pathways, whose expression is reduced in several different types of cancer. (PMID: 21680106).
发表文章
| Species | Application | Title |
|---|---|---|
Br J Pharmacol L-Hcy-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinemia. | ||
Ren Fail LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis | ||
Mol Cell Biochem PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation. | ||
Chin Med J (Engl) Higher intratumor than peritumor expression of DUSP6/MKP-3 is associated with recurrence after curative resection of hepatocellular carcinoma. | ||
Biochim Biophys Acta VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues. |