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验证数据展示

  • IF Staining of MCF-7 using CL488-12345

    IF Staining of MCF-7 using CL488-12345

    Immunofluorescent analysis of (-20°C Methanol) fixed MCF-7 cells using CoraLite® Plus 488 DYNC1H1 antibody (CL488-12345) at dilution of 1:200.

  • Featured Product
  • KD/KO验证

CoraLite® Plus 488-conjugated DYNC1H1 Polyclonal antibody

DYNC1H1 Polyclonal Antibody for IF/ICC
Cat No. CL488-12345

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, rat, zebrafish, mouse

应用

IF/ICC

别名

DHC1, DHC1a, DKFZp686P2245, DNCH1, Dnchc1, DNCL, DNECL, DYHC, DYNC1H1, Dynein heavy chain, cytosolic, HL 3, KIAA0325, p22

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite® Plus 488
规格: 

-/ -

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经过测试的应用

Positive IF/ICC detected inMCF-7 cells
Planning an IHC experiment? We recommend our IHCeasy DYNC1H1 Ready-To-Use IHC Kit. DYNC1H1 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 12345-1-AP

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-12345 targets DYNC1H1 in IF/ICC applications and shows reactivity with human, rat, zebrafish, mouse samples.

经测试应用 IF/ICC Application Description
经测试反应性 human, rat, zebrafish, mouse
免疫原 DYNC1H1 fusion protein Ag2999 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 dynein, cytoplasmic 1, heavy chain 1
别名 DHC1, DHC1a, DKFZp686P2245, DNCH1, Dnchc1, DNCL, DNECL, DYHC, DYNC1H1, Dynein heavy chain, cytosolic, HL 3, KIAA0325, p22
计算分子量 4646 aa, 532 kDa
观测分子量 532 kDa
GenBank蛋白编号BC021297
基因名称 DYNC1H1
Gene ID (NCBI) 1778
RRIDAB_3083925
偶联类型 CoraLite® Plus 488 Fluorescent Dye
最大激发/发射波长493 nm / 522 nm
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ14204
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Dyneins are a group of microtubule-activated ATPases that serve to convert chemical energy into mechanical energy. It can be divided into 2 large subgroups, namely, the axonemal and cytoplasmic dyneins. The conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains. DYNC1H1 is a cytoplasmic dynein and belongs to the dynein heavy chain family. It acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. DYNC1H1 has been implicated in the degeneration of dopaminergic neuron axons and motor neurons in PD patients..

实验方案

Product Specific Protocols
IF protocol for CL Plus 488 DYNC1H1 antibody CL488-12345Download protocol
Standard Protocols
Click here to view our Standard Protocols