Anti-Mouse E-Cadherin Rabbit Recombinant Antibody, PBS Only
E-Cadherin Uni-rAbTM Recombinant Antibody for FC
Host / Isotype
Rabbit / IgG
Reactivity
mouse, canine
Applications
FC
Conjugate
Unconjugated
CloneNo.
241282C1
验证数据展示
产品信息
The immunogen of 98140-1-PBS is E-Cadherin Fusion Protein expressed in E. coli.
Tested Applications | FC Application Description |
Tested Reactivity | mouse, canine |
Immunogen | Fusion Protein 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | cadherin 1 |
Synonyms | Um, L CAM, Ecad, Cdh1, cadherin 1 |
Calculated Molecular Weight | 98kDa |
GenBank Accession Number | NM_009864.3 |
Gene Symbol | E-cadherin |
Gene ID (NCBI) | 12550 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
UNIPROT ID | P09803 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CD324, CDH1 (cadherin 1) or CAM 120/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness.