验证数据展示
产品信息
20894-1-PBS targets E-selectin/CD62E in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | E-selectin/CD62E fusion protein Ag14944 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | selectin E |
Synonyms | CD62E, E-selectin, CD62 antigen-like family member E, ELAM1, ELAM 1 |
Calculated Molecular Weight | 610 aa, 67 kDa |
Observed Molecular Weight | 115 kDa |
GenBank Accession Number | BC142711 |
Gene Symbol | CD62E |
Gene ID (NCBI) | 6401 |
RRID | AB_10755287 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | P16581 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
E-selectin, also known as ELAM-1 or CD62E, is a member of the selectin family of adhesion molecules that also includes L-selectin and P-selectin. E-selectin is an inducible endothelial cell surface molecule. Its expression on endothelial cells is transcriptionally upregulated by various proinflammatory substances such as IL-1, TNFα and lipopolysaccharide (LPS). Besides, it can be secreted by endothelial cells, and can be detected in a soluble form (sE-selectin) in serum. During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. (PMID: 2827173; 1382417; 8943958)