验证数据展示
产品信息
81768-1-PBS targets EIF2AK1 in Indirect ELISA, WB applications and shows reactivity with human samples.
| 经测试应用 | Indirect ELISA, WB Application Description |
| 经测试反应性 | human |
| 免疫原 | EIF2AK1 fusion protein Ag14236 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | eukaryotic translation initiation factor 2-alpha kinase 1 |
| 别名 | Heme regulated inhibitor, Heme controlled repressor, HCR, Eukaryotic translation initiation factor 2-alpha kinase 1, EC:2.7.11.1 |
| 计算分子量 | 630 aa, 71 kDa |
| 观测分子量 | 71 kDa |
| GenBank蛋白编号 | BC006524 |
| 基因名称 | EIF2AK1 |
| Gene ID (NCBI) | 27102 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q9BQI3 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Eukaryotic initiation factor 2a (eIF2a), which is a critical component in the formation of the translation initiation ternary complex (eIF2a/GTP/methionyl transfer RNA), plays a key role in the ER stress response. EIF2AK1, which is activated by heme deficiency and other stimuli, is a major kinase that phosphorylates EIF2-alpha. Phosphorylation of the alpha subunit of EIF2 downregulates protein synthesis in response to various stress conditions. EIF2AK1 has some isoforms with 630aa, 577aa and 422aa.