验证数据展示
产品信息
68315-1-PBS targets EXOSC10 in WB, IF/ICC, IP, ELISA applications and shows reactivity with Human samples.
Tested Applications | WB, IF/ICC, IP, ELISA Application Description |
Tested Reactivity | Human |
Immunogen | EXOSC10 fusion protein Ag28587 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | exosome component 10 |
Synonyms | Autoantigen PM/Scl 2, EXOSC10, exosome component 10, p2, p3, p4, PM Scl, PM/Scl 100, PMSCL, PMSCL2, RRP6, Rrp6p |
Calculated Molecular Weight | 98 kDa |
Observed Molecular Weight | 98 kDa |
GenBank Accession Number | BC039901 |
Gene Symbol | EXOSC10 |
Gene ID (NCBI) | 5394 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q01780 |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a neuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl 2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl paitents. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.