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  • Featured Product
  • KD/KO Validated

FAF2 Monoclonal antibody, PBS Only

FAF2 Monoclonal Antibody for WB,Indirect ELISA,IHC

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse

Applications

WB,Indirect ELISA,IHC

Conjugate

Unconjugated

CloneNo.

3H6D2

Cat No : 66629-1-PBS

Print datasheet

Synonyms

ETEA, FAF2, FAS associated factor 2, KIAA0887, Protein ETEA, UBXD8, UBXN3B

验证数据展示

  • WB analysis of HeLa using 66629-1-Ig (same clone as 66629-1-PBS)

    WB analysis of HeLa using 66629-1-Ig (same clone as 66629-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 66629-1-Ig (FAF2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66629-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 66629-1-Ig (same clone as 66629-1-PBS)

    IHC staining of human breast cancer using 66629-1-Ig (same clone as 66629-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66629-1-Ig (FAF2 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66629-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 66629-1-Ig (same clone as 66629-1-PBS)

    WB analysis of HeLa using 66629-1-Ig (same clone as 66629-1-PBS)

    WB result of FAF2 antibody (66629-1-Ig; 1:3000; incubated at room temperature for 1.5 hours) with sh-Control and sh-FAF2 transfected HeLa cells. This data was developed using the same antibody clone with 66629-1-PBS in a different storage buffer formulation.

产品信息

66629-1-PBS targets FAF2 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, mouse samples.

Tested Applications WB,Indirect ELISA,IHC Application Description
Tested Reactivity Human, mouse
Immunogen FAF2 fusion protein Ag21536 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name Fas associated factor family member 2
Synonyms ETEA, FAF2, FAS associated factor 2, KIAA0887, Protein ETEA, UBXD8, UBXN3B
Calculated Molecular Weight 445 aa, 53 kDa
Observed Molecular Weight 51 kDa
GenBank Accession NumberBC014001
Gene Symbol FAF2
Gene ID (NCBI) 23197
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ96CS3
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

Protein ETEA (FAF2, or UBXD8) is a homolog to Fas-associated factor 1 (FAF1), which is involved in Fas-mediated apoptosis. ETEA protein directly interacts with and negatively regulates neurofibromin. ETEA contains both UBA and UBX domains and overexpression of ETEA downregulates neurofibromin in human cells. It may play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. ETEA is highly expressed in peripheral blood of patients with atopic dermatitis (AD) compared to normal individuals, and may regulate the resistance to apoptosis that is observed in T cells and eosinophils of AD patients.