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验证数据展示

  • WB analysis using 67986-1-Ig (same clone as 67986-1-PBS)

    WB analysis using 67986-1-Ig (same clone as 67986-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67986-1-Ig (FAH antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated GAPDH Monoclonal antibody (HRP-60004) as loading control. This data was developed using the same antibody clone with 67986-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 67986-1-Ig (same clone as 67986-1-PBS)

    IF Staining of HepG2 using 67986-1-Ig (same clone as 67986-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed HepG2 cells using FAH antibody (67986-1-Ig, Clone: 2F8E11 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67986-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 67986-1-Ig (same clone as 67986-1-PBS)

    IF Staining of HepG2 using 67986-1-Ig (same clone as 67986-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using FAH antibody (67986-1-Ig, Clone: 2F8E11 ) at dilution of 1:400 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Mouse Recombinant Secondary Antibody (H+L) (RGAM002). This data was developed using the same antibody clone with 67986-1-PBS in a different storage buffer formulation.

FAH Monoclonal antibody, PBS Only

FAH Monoclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 67986-1-PBS

产品说明书

CloneNo. 2F8E11

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse, rat, pig

应用

WB, IF/ICC, Indirect ELISA

别名

Fumarylacetoacetate hydrolase, FAA, EC:3.7.1.2, Beta-diketonase, 2F8E11

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

67986-1-PBS targets FAH in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat, pig
免疫原 FAH fusion protein Ag6704 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 fumarylacetoacetate hydrolase (fumarylacetoacetase)
别名 Fumarylacetoacetate hydrolase, FAA, EC:3.7.1.2, Beta-diketonase, 2F8E11
计算分子量 46 kDa
观测分子量 40-45 kDa
GenBank蛋白编号BC002527
基因名称 FAH
Gene ID (NCBI) 2184
RRIDAB_2918735
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP16930
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

FAH is also named as FAA(fumarylacetoacetase), the last enzyme in tyrosine degradation, functionally important in the liver and kidney(PMID:8473520). FAH is a metabolic enzyme catalyzing the last step of tyrosine and phenylalanine catabolism: the hydrolysis of fumarylacetoacetate into acetoacetate and fumarate. In humans, deficiency of this activity is associated with the metabolic disease hereditary tyrosinaemia type I, which is also known as hepatorenal tyrosinaemia(PMID:17768357).