验证数据展示
产品信息
67986-1-PBS targets FAH in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.
Tested Applications | WB, IF/ICC, Indirect ELISA Application Description |
Tested Reactivity | human, mouse, rat, pig |
Immunogen | FAH fusion protein Ag6704 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | fumarylacetoacetate hydrolase (fumarylacetoacetase) |
Synonyms | Fumarylacetoacetate hydrolase, FAA, EC:3.7.1.2, Beta-diketonase, 2F8E11 |
Calculated Molecular Weight | 46 kDa |
Observed Molecular Weight | 40-45 kDa |
GenBank Accession Number | BC002527 |
Gene Symbol | FAH |
Gene ID (NCBI) | 2184 |
RRID | AB_2918735 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P16930 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
FAH is also named as FAA(fumarylacetoacetase), the last enzyme in tyrosine degradation, functionally important in the liver and kidney(PMID:8473520). FAH is a metabolic enzyme catalyzing the last step of tyrosine and phenylalanine catabolism: the hydrolysis of fumarylacetoacetate into acetoacetate and fumarate. In humans, deficiency of this activity is associated with the metabolic disease hereditary tyrosinaemia type I, which is also known as hepatorenal tyrosinaemia(PMID:17768357).