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FAH Monoclonal antibody, PBS Only

FAH Monoclonal Antibody for WB, IF/ICC, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human, mouse, rat, pig

Applications

WB, IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2F8E11

Cat no : 67986-1-PBS

Print datasheet

Synonyms

Fumarylacetoacetate hydrolase, FAA, EC:3.7.1.2, Beta-diketonase, 2F8E11

验证数据展示

  • WB analysis using 67986-1-Ig (same clone as 67986-1-PBS)

    WB analysis using 67986-1-Ig (same clone as 67986-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67986-1-Ig (FAH antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated GAPDH Monoclonal antibody (HRP-60004) as loading control. This data was developed using the same antibody clone with 67986-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 67986-1-Ig (same clone as 67986-1-PBS)

    IF Staining of HepG2 using 67986-1-Ig (same clone as 67986-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed HepG2 cells using FAH antibody (67986-1-Ig, Clone: 2F8E11 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67986-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 67986-1-Ig (same clone as 67986-1-PBS)

    IF Staining of HepG2 using 67986-1-Ig (same clone as 67986-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using FAH antibody (67986-1-Ig, Clone: 2F8E11 ) at dilution of 1:400 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Mouse Recombinant Secondary Antibody (H+L) (RGAM002). This data was developed using the same antibody clone with 67986-1-PBS in a different storage buffer formulation.

产品信息

67986-1-PBS targets FAH in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.

Tested Applications WB, IF/ICC, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat, pig
Immunogen FAH fusion protein Ag6704 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name fumarylacetoacetate hydrolase (fumarylacetoacetase)
Synonyms Fumarylacetoacetate hydrolase, FAA, EC:3.7.1.2, Beta-diketonase, 2F8E11
Calculated Molecular Weight 46 kDa
Observed Molecular Weight 40-45 kDa
GenBank Accession NumberBC002527
Gene Symbol FAH
Gene ID (NCBI) 2184
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP16930
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

FAH is also named as FAA(fumarylacetoacetase), the last enzyme in tyrosine degradation, functionally important in the liver and kidney(PMID:8473520). FAH is a metabolic enzyme catalyzing the last step of tyrosine and phenylalanine catabolism: the hydrolysis of fumarylacetoacetate into acetoacetate and fumarate. In humans, deficiency of this activity is associated with the metabolic disease hereditary tyrosinaemia type I, which is also known as hepatorenal tyrosinaemia(PMID:17768357).