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验证数据展示

  • WB analysis of HeLa using 83488-4-RR (same clone as 83488-4-PBS)

    WB analysis of HeLa using 83488-4-RR (same clone as 83488-4-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 83488-4-RR (FAM38B antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83488-4-PBS in a different storage buffer formulation.

  • FC experiment of A431 using 83488-4-RR (same clone as 83488-4-PBS)

    FC experiment of A431 using 83488-4-RR (same clone as 83488-4-PBS)

    1x10^6 A431 cells were intracellularly stained with 0.25 ug Fam38b Recombinant Antibody (83488-4-RR, Clone:240406E5) and APC-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Isotype Control (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 83488-4-PBS in a different storage buffer formulation.

  • Cytometric bead array standard curve of MP00488-2

    Cytometric bead array standard curve of MP00488-2

    Cytometric bead array standard curve of MP00488-2, FAM38B Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 83488-4-PBS. Detection antibody: 83488-1-PBS. Standard: Ag24528. Range: 0.313-40 ng/mL.

  • Cytometric bead array standard curve of MP00488-3

    Cytometric bead array standard curve of MP00488-3

    Cytometric bead array standard curve of MP00488-3, FAM38B Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 83488-4-PBS. Detection antibody: 83488-2-PBS. Standard: Ag24528. Range: 0.313-40 ng/mL.

  • Affinity and Kinetic Characterization of 83488-4-RR

    Affinity and Kinetic Characterization of 83488-4-RR

    Biolayer interferometry (BLl) kinetic assays of 83488-4-RR against Human FAM38B were performed. The affinity constant is 3.8 nM.

FAM38B Recombinant antibody, PBS Only (Capture)

FAM38B Uni-rAbTM Recombinant Antibody for WB, Cytometric bead array, Indirect ELISA
Cat No. 83488-4-PBS

产品说明书

CloneNo. 240406E5

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Cytometric bead array, Indirect ELISA

别名

Piezo2, 240406E5, C18orf30, Transmembrane protein C18orf30

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

83488-4-PBS targets FAM38B as part of a matched antibody pair:

MP00488-2: 83488-4-PBS capture and 83488-1-PBS detection (validated in Cytometric bead array)

MP00488-3: 83488-4-PBS capture and 83488-2-PBS detection (validated in Cytometric bead array)

Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

经测试应用 WB, Cytometric bead array, Indirect ELISA Application Description
经测试反应性 human
免疫原 FAM38B fusion protein Ag24528 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 family with sequence similarity 38, member B
别名 Piezo2, 240406E5, C18orf30, Transmembrane protein C18orf30
计算分子量 318 kDa
观测分子量250-310 kDa, 80 kDa
GenBank蛋白编号AB527139
基因名称 FAM38B
Gene ID (NCBI) 63895
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ9H5I5
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

FAM38B, also named as PIEZO2, is a mechanosensitive, rapidly inactivating (RI) ion channel which is open and converts the mechanical stimulus signals into bioelectrical signals after stimulated by mechanical signals. FAM38B has been recently identified in dorsal root ganglion (DRG) neurons to mediate tactile transduction. It plays an important role in the biological process, maintaining cell metabolism and cell migration. Loss-of-function mutations in the human FAM38B gene cause an autosomal recessive syndrome of muscular atrophy with perinatal respiratory distress, arthrogryposis, and scoliosis.The 80 kDa band detected by SDS-PAGE can be caused by alternative splicing (PMID: 34335288, 37227654).