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验证数据展示

  • IHC staining of mouse skeletal muscle using 28541-1-AP (same clone as 28541-1-PBS)

    IHC staining of mouse skeletal muscle using 28541-1-AP (same clone as 28541-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 28541-1-AP (FBXO32 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28541-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with FBXO32 antibody included

FBXO32 Polyclonal antibody, PBS Only

FBXO32 Polyclonal Antibody for IHC, Indirect ELISA
Cat No. 28541-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy FBXO32 Ready-To-Use IHC Kit. FBXO32 primary antibody included.

产品信息

28541-1-PBS targets FBXO32 in IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 FBXO32 fusion protein Ag29410 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 F-box protein 32
别名
计算分子量 355 aa, 42 kDa
GenBank蛋白编号BC024030
基因名称 FBXO32
Gene ID (NCBI) 114907
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ969P5
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

FBXO32 (F box only protein 32), also known as Atrogin 1 or MAFbx, is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif F-box. This protein is an E3 ubiquitin ligase that is markedly up-regulated in muscle atrophy. FBXO32 is thus a potential drug target for the treatment of muscle atrophy. Some data support that FBXO32 may play an important role in tumorigenesis. Recent study reveal that FBXO32 targets the oncogenic protein c-Myc for ubiquitination and degradation through the proteasome pathway.