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FBXO32 Polyclonal antibody, PBS Only

FBXO32 Polyclonal Antibody for IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 28541-1-PBS

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Synonyms

验证数据展示

  • IHC staining of mouse skeletal muscle using 28541-1-AP (same clone as 28541-1-PBS)

    IHC staining of mouse skeletal muscle using 28541-1-AP (same clone as 28541-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 28541-1-AP (FBXO32 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28541-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with FBXO32 antibody included
Planning an IHC experiment? We recommend our IHCeasy FBXO32 Ready-To-Use IHC Kit. FBXO32 primary antibody included.

产品信息

28541-1-PBS targets FBXO32 in IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications IHC, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen FBXO32 fusion protein Ag29410 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name F-box protein 32
Synonyms
Calculated Molecular Weight 355 aa, 42 kDa
GenBank Accession NumberBC024030
Gene Symbol FBXO32
Gene ID (NCBI) 114907
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ969P5
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

FBXO32 (F box only protein 32), also known as Atrogin 1 or MAFbx, is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif F-box. This protein is an E3 ubiquitin ligase that is markedly up-regulated in muscle atrophy. FBXO32 is thus a potential drug target for the treatment of muscle atrophy. Some data support that FBXO32 may play an important role in tumorigenesis. Recent study reveal that FBXO32 targets the oncogenic protein c-Myc for ubiquitination and degradation through the proteasome pathway.