验证数据展示
产品信息
30356-1-PBS targets FCGR3A/CD16a in WB, IF-P, Indirect ELISA applications and shows reactivity with human samples.
经测试应用 | WB, IF-P, Indirect ELISA Application Description |
经测试反应性 | human |
免疫原 | FCGR3A/CD16a fusion protein Ag1281 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) |
别名 | CD16, Fc gamma RIII alpha, Fc gamma RIII, CD16-II, CD16a antigen |
计算分子量 | 29 kDa |
观测分子量 | 65-70 kDa |
GenBank蛋白编号 | BC036723 |
基因名称 | CD16a |
Gene ID (NCBI) | 2214 |
ENSEMBL Gene ID | ENSG00000203747 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | P08637 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CD16 is a low affinity Fc receptor. It has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), encoded by two nearly identical genes, FCGR3A and the FCGR3B. In humans, FcγRIIIa/CD16a is a type I transmembrane receptor expressed on macrophages and NK cells. FcγRIIIb/CD16b is a GPI-linked Fc-receptor highly expressed on neutrophils. The two proteins differ by only four amino acid residues in the mature proteins(PMID: 30361439). FCGR3A has a calculated molecular weight of 29 kDa, with an apparent molecular weight of 50-80 kDa due to extensive glycosylation (PMID: 30655272; PMID: 27914599). The antibody is specific for FCGR3A/CD16a.