验证数据展示
产品信息
82248-1-PBS targets FIS1 in WB, IHC, IF/ICC, FC (Intra), IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
经测试应用 | WB, IHC, IF/ICC, FC (Intra), IP, Indirect ELISA Application Description |
经测试反应性 | human, mouse, rat |
免疫原 | FIS1 fusion protein Ag1409 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) |
别名 | TPR repeat protein 11, hFis1, FIS1 homolog, CGI-135, CGI 135 |
计算分子量 | 17 kDa |
观测分子量 | 15 kDa |
GenBank蛋白编号 | BC009428 |
基因名称 | FIS1 |
Gene ID (NCBI) | 51024 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | Q9Y3D6 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Fis1 (fission 1) is an integral mitochondrial outer membrane protein that participates in mitochondrial fission by interacting with dynamin-related protein 1 (Drp1). Excessive mitochondrial fission is associated with the pathology of a number of neurodegenerative or neurodevelopmental diseases. Increased expression of Fis1 has been found in Huntington's disease (HD)-affected brain, Alzheimer's disease (AD) patients, and autism spectrum disorder. (PMID: 21257639, 21459773, 23333625)