验证数据展示
产品信息
68262-1-PBS targets FUS/TLS in WB, IHC, IF-P, FC (Intra), IP, ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Applications | WB, IHC, IF-P, FC (Intra), IP, ELISA Application Description |
Tested Reactivity | human, mouse, rat |
Immunogen | FUS/TLS fusion protein Ag2150 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | fusion (involved in t(12;16) in malignant liposarcoma) |
Synonyms | FUS, ALS6, ALS, 75 kDa DNA-pairing protein, 75 kDa DNA pairing protein |
Calculated Molecular Weight | 75 kDa |
Observed Molecular Weight | 53 kDa, 68-75 kDa |
GenBank Accession Number | BC026062 |
Gene Symbol | FUS/TLS |
Gene ID (NCBI) | 2521 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | P35637 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
FUS (also named TLS and POMp75) belongs to the RRM TET family. FUS may play a role in the maintenance of genomic integrity; it binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. FUS is also an RNA-binding protein, and its links to neurodegenerative disease proffer the intriguing possibility that altered RNA metabolism or RNA processing may underlie or contribute to neuron degeneration[PMID: 22640227]. FUS may be a cause of angiomatoid fibrous histiocytoma (AFH) and is implicated in certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementias (FTDs) such as frontotemporal lobar dementia with ubiquitin inclusions (FTLD-U)(PMID: 22640227). Multiple phosphorylation on the N terminus of FUS caused that FUS was detected 68-75 kDa (PMID:24899704).