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FcRn Monoclonal antibody, PBS Only

FcRn Monoclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2H4A5

Cat no : 67944-1-PBS

Print datasheet

Synonyms

alpha chain, FCGRT, FCRN, Neonatal Fc receptor

验证数据展示

  • WB analysis using 67944-1-Ig (same clone as 67944-1-PBS)

    WB analysis using 67944-1-Ig (same clone as 67944-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67944-1-Ig (FcRn antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67944-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 67944-1-Ig (same clone as 67944-1-PBS)

    IHC staining of human liver using 67944-1-Ig (same clone as 67944-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 67944-1-Ig (FcRn antibody) at dilution of 1:10000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67944-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 67944-1-Ig (same clone as 67944-1-PBS)

    IHC staining of human liver using 67944-1-Ig (same clone as 67944-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 67944-1-Ig (FcRn antibody) at dilution of 1:10000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67944-1-PBS in a different storage buffer formulation.

产品信息

67944-1-PBS targets FcRn in WB, IHC, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity Human
Immunogen FcRn fusion protein Ag31173 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name Fc fragment of IgG, receptor, transporter, alpha
Synonyms alpha chain, FCGRT, FCRN, Neonatal Fc receptor
Calculated Molecular Weight 40 kDa
Observed Molecular Weight 35-40 kDa
GenBank Accession NumberBC008734
Gene Symbol FcRn
Gene ID (NCBI) 2217
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP55899
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The neonatal Fc receptor for IgG (FcRn) is a membrane-associated receptor which acts as a key determinant of IgG homeostasis. FcRn is similar in structure to major histocompatibility class I molecules. It is a heterodimer composed of a alpha chain associated with β2-microglobulin. FcRn transfers IgG from the mother to the fetus across the placenta and the proximal small intestine. In addition, throughout life, FcRn protects IgG from degradation and thus regulates the serum half-life of IgG (PMID: 17703228).