验证数据展示
产品信息
68513-1-PBS targets GATM in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.
Tested Applications | WB, Indirect ELISA Application Description |
Tested Reactivity | human, mouse, rat, pig |
Immunogen | GATM fusion protein Ag3754 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
Synonyms | Transamidinase, L-arginine:glycine amidinotransferase, EC:2.1.4.1, AGAT, 1D12G5 |
Calculated Molecular Weight | 423 aa, 48 kDa |
Observed Molecular Weight | 48 kDa |
GenBank Accession Number | BC004141 |
Gene Symbol | GATM |
Gene ID (NCBI) | 2628 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | P50440 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
GATM, also known as AGAT, produces ornithine and guanidinoacetate (GAA) from arginine and glycine, and is a key enzyme for creatine synthesis. GATM deficiency in early infancy causes neurodevelopmental delay. GATM is predominantly expressed in kidney and pancreas in adults. Decrease of GAMT proteins was observed in proximal tubule damage cases, which links GATM as a general marker for proximal tubule damage. Alternative splicing of GATM generates three isoforms with molecular weights between 44 kDa to 48 kDa.