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GBP2 Monoclonal antibody, PBS Only

GBP2 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2D7G4

Cat no : 68559-1-PBS

Print datasheet

Synonyms

GBP 2, GBP2, GTP binding protein 2, HuGBP 2

验证数据展示

  • WB analysis using 68559-1-Ig (same clone as 68559-1-PBS)

    WB analysis using 68559-1-Ig (same clone as 68559-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68559-1-Ig (GBP2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68559-1-PBS in a different storage buffer formulation.

产品信息

68559-1-PBS targets GBP2 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human
Immunogen GBP2 fusion protein Ag24108 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name guanylate binding protein 2, interferon-inducible
Synonyms GBP 2, GBP2, GTP binding protein 2, HuGBP 2
Calculated Molecular Weight 591 aa, 67 kDa
Observed Molecular Weight 67 kDa
GenBank Accession NumberBC022272
Gene Symbol GBP2
Gene ID (NCBI) 2634
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP32456
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

GBP2 is a member of the GTPase family and is crucial to host immunity against pathogens. GBP2 is also used as a marker of interferon (IFN) responsiveness, because it is one of the most highly expressed genes after IFN-γ stimulation. Increased GBP2 expression is also associated with a better prognosis in breast cancer and may have a role in T-cell defense against breast cancer. Interestingly, GBP2 expression in NIH/3T3 fibroblasts inhibited Rac activation and matrix metalloproteinase-9 expression, suggesting a possible role for GBP2 in regulating cancer metastasis. The molecular weight of GBP2 is 67 kDa. (PMID: 29072687, 35383115)