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验证数据展示

  • IF Staining of human liver cancer using CL594-67216

    IF Staining of human liver cancer using CL594-67216

    Immunofluorescent analysis of (4% PFA) fixed human liver cancer tissue using CoraLite®594 GCK antibody (CL594-67216, Clone: 1C3A3 ) at dilution of 1:200.

  • IF Staining of human liver cancer using CL594-67216

    IF Staining of human liver cancer using CL594-67216

    Immunofluorescent analysis of (4% PFA) fixed human liver cancer tissue using CoraLite®594 GCK antibody (CL594-67216, Clone: 1C3A3 ) at dilution of 1:200.

CoraLite®594-conjugated GCK Monoclonal antibody

GCK Monoclonal Antibody for IF-P
Cat No. CL594-67216

产品说明书

CloneNo. 1C3A3

宿主/亚型

Mouse / IgG1

种属反应性

Human, Mouse, Rat, Pig

应用

IF-P

别名

GCK, GK, GLK, Glucokinase, glucokinase (hexokinase 4), Hexokinase 4, Hexokinase D, Hexokinase type IV, HHF3, HK IV, HK4, HKIV, HXKP, MODY2

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite®594
规格: 

-/ -

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经过测试的应用

Positive IF-P detected inhuman liver cancer tissue
Planning an IHC experiment? We recommend our IHCeasy GCK Ready-To-Use IHC Kit. GCK primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 67216-1-Ig

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)-PIF-P : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL594-67216 targets GCK in IF-P applications and shows reactivity with Human, Mouse, Rat, Pig samples.

经测试应用 IF-P Application Description
经测试反应性 Human, Mouse, Rat, Pig
免疫原 GCK fusion protein Ag8116 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 glucokinase (hexokinase 4)
别名 GCK, GK, GLK, Glucokinase, glucokinase (hexokinase 4), Hexokinase 4, Hexokinase D, Hexokinase type IV, HHF3, HK IV, HK4, HKIV, HXKP, MODY2
计算分子量 52 kDa
观测分子量 52 kDa
GenBank蛋白编号BC001890
基因名称 GCK
Gene ID (NCBI) 2645
RRIDAB_2920098
偶联类型 CoraLite®594 Fluorescent Dye
最大激发/发射波长588 nm / 604 nm
形式 Liquid
纯化方式Protein G purification
UNIPROT IDP35557
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Glucokinase (GCK) is a structurally and functionally unique member of hexokinase family. It is expressed only in mammalian liver and pancreatic islet beta cells. Because of its unique functional characteristics, the enzyme plays an important regulatory role in glucose metabolism.The rate of glucose metabolism in liver and pancreas is a function of the activity of the enzyme(PMID:1740341). Moreover, GCK has been found to have relationship with diabetes. Defects in GCK are the cause of maturity-onset diabetes of the young type 2 (MODY2) and familial hyperinsulinemic hypoglycemia type 3 (HHF3). It has 3 isoforms produced by alternative splicing with the same molecular mass of 52 kDa.

实验方案

Product Specific Protocols
IF protocol for CL594 GCK antibody CL594-67216Download protocol
Standard Protocols
Click here to view our Standard Protocols