验证数据展示
产品信息
84199-1-PBS targets Geminin in IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
经测试应用 | IF/ICC, Indirect ELISA Application Description |
经测试反应性 | human |
免疫原 | Geminin fusion protein Ag1076 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | geminin, DNA replication inhibitor |
别名 | GMNN, MGORS6, Gem, 240835E6 |
计算分子量 | 24 kDa |
GenBank蛋白编号 | BC005185 |
基因名称 | GMNN |
Gene ID (NCBI) | 51053 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purfication |
UNIPROT ID | O75496 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
GMNN, also designated geminin, contains 212 amino acids and has a destruction box sequence (RRTLKVIQP). GMNN participates in ininhibiting DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the metaphase-anaphase transition of cell cycle's mitotic phase, which permits replication in the succeeding cell cycle. GMNN has a broad sedimentation profile ranging from about 25 kDa to 90 kDa, with a major peak at 30 kDa. Scanning of the signals shows that discrete peaks corresponding to apparent mass of 42.5 kDa and 66 kDa are present. (PMID: 15313623)