GPHN Monoclonal antibody, PBS Only
GPHN Monoclonal Antibody for WB, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1D7C4
验证数据展示
产品信息
67995-1-PBS targets GPHN in WB, Indirect ELISA applications and shows reactivity with Human samples.
| Tested Applications | WB, Indirect ELISA Application Description |
| Tested Reactivity | Human |
| Immunogen | GPHN fusion protein Ag23708 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | gephyrin |
| Synonyms | Domain E, GEPH, gephyrin, GPH, GPHN, GPHRYN, KIAA1385, MPT adenylyltransferase, MPT Mo transferase |
| Calculated Molecular Weight | 769 aa, 83 kDa |
| Observed Molecular Weight | 93 kDa |
| GenBank Accession Number | BC030016 |
| Gene Symbol | GPHN |
| Gene ID (NCBI) | 10243 |
| RRID | AB_2918744 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q9NQX3 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Gephyrin (GPHN) is an organizational protein that clusters and localizes the inhibitory glycine receptor (GlyR) and GABAA receptors to the microtubular matrix of the neuronal postsynaptic membrane. Mice deficient in gephyrin develop a hereditary molybdenum cofactor deficiency and a neurological phenotype that mimics startle disease (hyperekplexia). In non-neuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Two isoforms produced by alternative splicing have been described. The observed MW of Gephyrin is 93 kDa, larger than the predicated of 83 kDa, which may be due to the modifications on various phosphorylation sites.