验证数据展示
产品信息
67995-1-PBS targets GPHN in WB, Indirect ELISA applications and shows reactivity with Human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | Human |
| 免疫原 | GPHN fusion protein Ag23708 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | gephyrin |
| 别名 | Domain E, GEPH, gephyrin, GPH, GPHN, GPHRYN, KIAA1385, MPT adenylyltransferase, MPT Mo transferase |
| 计算分子量 | 769 aa, 83 kDa |
| 观测分子量 | 93 kDa |
| GenBank蛋白编号 | BC030016 |
| 基因名称 | GPHN |
| Gene ID (NCBI) | 10243 |
| RRID | AB_2918744 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | Q9NQX3 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Gephyrin (GPHN) is an organizational protein that clusters and localizes the inhibitory glycine receptor (GlyR) and GABAA receptors to the microtubular matrix of the neuronal postsynaptic membrane. Mice deficient in gephyrin develop a hereditary molybdenum cofactor deficiency and a neurological phenotype that mimics startle disease (hyperekplexia). In non-neuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Two isoforms produced by alternative splicing have been described. The observed MW of Gephyrin is 93 kDa, larger than the predicated of 83 kDa, which may be due to the modifications on various phosphorylation sites.